The mismatch repair (MMR) pathway promotes genome stability by controlling the fidelity of replication and recombination. The first step of the pathway involves recognition of the mismatch by heterodimers composed of MutS ...

Toxoplasma gondii is an apicomplexan parasite of medical and veterinary importance which causes Toxoplasmosis in humans. Great effort is currently being devoted towards the identification of novel drugs capable of targeting ...

Heterochromatin protein 1 paralogs (HP1α, β and γ in mammals) are not only central in heterochromatin organization, but have also been linked to transcriptional activation at euchromatic regions, maintenance of telomere ...

For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the most deleterious types of DNA lesions. DSB processing and repair can cause sequence deletions, loss of heterozygosity, and chromosome ...

The mismatch repair (MMR) system maintains genome integrity by correcting replication associated errors and inhibiting recombination between divergent DNA sequences. The basic features of the pathway have been highly ...

Homologous recombination is one of the major pathways for repairing DNA double strand breaks, the most deleterious of DNA lesions. Recent studies suggest that DNA methylation events target homologous recombination ...