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A change of view: Homologous recombination at single-molecule resolution
(Nature Publishing Group, 2018-04)
Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer. Our understanding of homologous recombination is built upon ...
A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria
(Cold Spring Harbor Laboratory Press, 2020)
The mismatch repair protein MSH6 regulates somatic recombination in Arabidopsis thaliana
(Elsevier Science, 2020-03)
The mismatch repair (MMR) pathway promotes genome stability by controlling the fidelity of replication and recombination. The first step of the pathway involves recognition of the mismatch by heterodimers composed of MutS ...
Homologous recombination and retention of a single form of most genes shape the highly chimeric mitochondrial genome of a cybrid plant
(Wiley, 2015-04-28)
The structure and evolution of angiosperm mitochondrial genomes are driven by extremely high rates of recombination and rearrangement. An excellent experimental system for studying these events is offered by cybrid plants, ...
Yeast Srs2 helicase promotes redistribution of single-stranded DNA-Bound RPA and Rad52 in homologous recombination regulation
(Elsevier B.V., 2017-10)
Srs2 is a super-family 1 helicase that promotes genome stability by dismantling toxic DNA recombination intermediates. However, the mechanisms by which Srs2 remodels or resolves recombination intermediates remain poorly ...
Double-strand breaks associated with repetitive DNA can reshape the genome
(Natl Acad SciencesWashingtonEUA, 2008)
Relationship between B-Cell-specific moloney murine leukemia virus integration site 1 (BMI-1) and homologous recombination regulatory genes in invasive ductal breast carcinomas
(F HERNANDEZMURCIA, 2013-08-02)
B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is a Polycomb group protein that is able to induce telomerase activity, enabling the immortalization of epithelial cells. Immortalized cells are more ...
GADD45α modulates DNA methylation induced by DNA damage during homologous recombination
(Biomédica, Mecatrónica y MecánicaEscuela de Ingeniería de Antioquia EIAUniversidad CES, 2014-04-23)
Homologous recombination is one of the major pathways for repairing DNA double strand breaks, the most
deleterious of DNA lesions. Recent studies suggest that DNA methylation events target homologous recombination ...
The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii
(Frontiers in Bioscience, 2016-05)
Toxoplasma gondii is an apicomplexan parasite of medical and veterinary importance which causes Toxoplasmosis in humans. Great effort is currently being devoted towards the identification of novel drugs capable of targeting ...