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HMG‐Like chromosomal proteins in Trypanosoma cruzi
(1992)
HMG‐like chromosomal proteins from Truypansoma cruzi were studies. Four HMG‐like proteins, designated HMG A, HMGA‐B, HMG‐C, and HMG‐E, were isolated and found to have molecular weights of 35.5 kd, 27.5 kd, 21.8 kd and 10.4 ...
Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2013-01-30)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
Design, synthesis, and docking of highly hypolipidemic agents:Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2013-02-26)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
IAF, QGF, and QDF peptides exhibit cholesterol-lowering activity through a statin-like HMG-CoA reductase regulation mechanism: In silico and in vitro approach
(2021-10-01)
In this study, in silico approaches are employed to investigate the binding mechanism of peptides derived from cowpea β-vignin and HMG-CoA reductase. With the obtained information, we designed synthetic peptides to evaluate ...
Desempenho do grupo de proteínas 1 de alta mobilidade (HMG1) e da interleucina 6 como preditores de desfechos resultantes do sangramento varicoso em pacientes com hepatopatia crônica avançada descompensada
(Universidade Federal de Minas GeraisBrasilMEDICINA - FACULDADE DE MEDICINAPrograma de Pós-Graduação em Ciências Aplicadas à Saúde do AdultoUFMG, 2019-08-06)
Introduction: Bleeding resulting from rupture of esophagogastric varices is considered a serious complication resulting from portal hypertension and potentially fatal in patients with advanced chronic liver disease. In ...
Policosanol modula la actividad de HMG-CoA reductasa en fibroblastos cultivados
(2001)
La biosíntesis de colesterol es estrictamente controlada por la 3-hidroxi-3-metilglutaril Coenzima A (HMG-CoA) reductasa. La transferencia de fibroblastos cultivados a un medio agotado en lípidos (LDM) regula los niveles ...
In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide
(2018-09-01)
Previous studies have shown that cowpea protein positively interferes with cholesterol metabolism. In this study, we evaluated the ability of the fraction containing peptides of <3 kDa, as well as that of the Gln-Asp-Phe ...
Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2012-11-28)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...