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HLA-G, -E and -F regulatory and coding region variability and haplotypes in the Beninese Toffin population sample
(2018-12-01)
HLA-G/E/F genes exhibit immunomodulatory properties and are expressed in placenta. Little attention has been devoted to the study of these genes in sub-Saharan African populations, which are yet the most diverse. To fill ...
HLA haplotypes in families with type 1 diabetes Haplotipos HLA en familias chilenas con diabetes tipo 1
(1998)
Background: Inherited susceptibility to type 1 diabetes is partially determined by HLA genes. HLA-DQA1 and DQB1 alleles have been chosen as the most sensitive susceptibility markers. Family studies are a good method to ...
HLA-G variability and haplotypes detected by massively parallel sequencing procedures in the geographicaly distinct population samples of Brazil and Cyprus
(2017-03-01)
The HLA-G molecule presents immunomodulatory properties that might inhibit immune responses when interacting with specific Natural Killer and T cell receptors, such as KIR2DL4, ILT2 and ILT4. Thus, HLA-G might influence ...
Evaluation of computational methods for the reconstruction of HLA haplotypes
(WILEY-BLACKWELL, 2010)
Human leukocyte antigen (HLA) haplotypes are frequently evaluated for population history inferences and association studies. However, the available typing techniques for the main HLA loci usually do not allow the determination ...
Insights into HLA-G genetics provided by worldwide haplotype diversity
(Frontiers Research Foundation, 2014-10-06)
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I genes, located within the major histocompatibility complex (MHC). HLA-G has been the target of most recent research regarding the function ...
HLA-F coding and regulatory segments variability determined by massively parallel sequencing procedures in a Brazilian population sample
(2016-10-01)
Human Leucocyte Antigen F (HLA-F) is a non-classical HLA class I gene distinguished from its classical counterparts by low allelic polymorphism and distinctive expression patterns. Its exact function remains unknown. It ...
Estrutura e variabilidade da região 3’não-traduzida dos genes HLA-A, HLA-C e HLA-G e perfil de ligação de microRNAs
(Universidade Estadual Paulista (Unesp), 2018-02-26)
O complexo gênico de Antígenos Leucocitário Humanos (HLA) é a região mais variável do genoma humano. Os genes HLA de classe I são divididos em clássicos e não clássicos, a depender de suas funções primárias, níveis de ...
The genetic diversity within the 1.4 kb HLA-G 5′ upstream regulatory region moderately impacts on cellular microenvironment responses
(2018-12-01)
The HLA-G 5'URR extending 1.4 kb from the ATG presents a unique set of regulatory elements among HLA genes. Several variable sites have been described that coincide with or are close to these elements, thus HLA-G 5′URR ...
HLA-F displays highly divergent and frequent haplotype lineages associated with different mRNA expression levels
(2019-02-01)
HLA-F is one of the most conserved loci among the HLA gene family. The exact function of HLA-F is still under investigation. HLA-F might present tolerogenic features, participate in the stabilization of HLA molecules in ...