Buscar
Mostrando ítems 1-10 de 206
Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression
(Elsevier, 2017-04)
Histone post-translational modification, mediated by histone acetyltransferases and deacetylases, is one of the most studied factors affecting gene expression. Recent data showing differential histone acetylation states ...
Editorial: Epigenetic Therapy With Histone Deacetylase Inhibitors: Implications for Cancer Treatment
(Frontiers Media Sa, 2021-04-06)
Chemosensitizing activity of histone deacetylases inhibitory cyclic hydroxamic acids for combination chemotherapy of lymphatic leukemia
(Bentham Science Publishers B.V., 2018)
Supplementation with the histone deacetylase inhibitor trichostatin A during in vitro culture of bovine embryos
(2013-02-01)
Summary Trichostatin A (TSA) is a histone deacetylase inhibitor that induces histone hyperacetylation and increases gene expression levels. The aim of the present study was to establish a suitable condition for the use of ...
Supplementation with the histone deacetylase inhibitor trichostatin A during in vitro culture of bovine embryos
(2013-02-01)
Summary Trichostatin A (TSA) is a histone deacetylase inhibitor that induces histone hyperacetylation and increases gene expression levels. The aim of the present study was to establish a suitable condition for the use of ...
Atividade antitumoral de inibidores de Histona Desacetilase como estratégia terapêutica contra o câncer cervical humano associado ao Papilomavírus Humano (HPV)
(Universidade Estadual Paulista (Unesp), 2021-12-16)
O câncer de colo de útero é o quarto tipo mais comum de câncer entre as mulheres. Sua principal causa é a infecção persistente pelo vírus Papilomavírus Humano (HPV) de alto risco, como o tipo 16 e o 18. As proteínas E6 e ...
Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus
(2021-01-28)
The role of epigenetic modifications on the carcinogenesis process has received a lot of attention in the last years. Among those, histone acetylation is a process regulated by histone deacetylases (HDAC) and histone ...
Short- and long-term effects of nicotine and the histone deacetylase inhibitor phenylbutyrate on novel object recognition in zebrafish
(Springer, 2017-03)
Rationale: Zebrafish have a sophisticated color- and shape-sensitive visual system, so we examined color cue-based novel object recognition in zebrafish. We evaluated preference in the absence or presence of drugs that ...
Synthesis and pharmacological evaluation of histone deacetylase inhibitors as fetal hemoglobin inducers
(Amer Chemical Soc, 2018-03-18)