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High-dose coenzyme Q10-loaded oleogels for oral therapeutic supplementation
(Elsevier Science, 2019-02)
Coenzyme Q10 (CoQ10) is a mitochondrial respiratory cofactor and potent endogenous antioxidant. In CoQ10-deficient patients, early treatment with high-oral doses (5–50 mg/kg/day) can limit the progression of renal disease ...
Genotoxic risk in humans and acute toxicity in rats of a novel oral high-dose coenzyme Q10 oleogel
(Elsevier, 2021-06)
Coenzyme Q10 (CoQ10) supplementation has demonstrated to be safe and effective in primary and secondary CoQ10 deficiencies. Previously, we have designed a high-dose CoQ10 oleogel (1 g/disk) with excipients used in quantities ...
High dose Coenzyme Q10 oleogels designed for orphan therapy
(Instituto de la Química y Metabolismo del Fármaco, 2018)
Recently, Coenzyme Q10 (CoQ10) was established by the FDA as an orphan drug and its therapeutic recommended dose increased significantly, reaching values up to 50 mg/kg/day. Patients with CoQ10 deficiency usually have ...
Amitriptyline down-regulates coenzyme Q10 biosynthesis in lung cancer cells
(2017)
Amitriptyline, a tricyclic antidepressant, has been proposed as an antitumoral drug in oxidative therapy. Its proapoptotic effects, mediated by high reactive oxygen species generation, have been already described. In this ...
Bioavailability of coenzyme Q10 loaded in an oleogel formulation for oral therapy: Comparison with a commercial-grade solid formulation
(Elsevier Science, 2020-05)
Coenzyme Q10 (CoQ10) is essential in mitochondrial bioenergetics and is a potent endogenous antioxidant. Low CoQ10 levels are associated with neurodegenerative, metabolic, muscular and cardiovascular disorders. Early ...
Development of orphan coenzyme q10 liquid formulations for pediatric patiens
(Elsevier Science, 2013-08)
Coenzyme Q10 (CoQ10) deficiency is involved in cardiomyopathies and degenerative muscle and neuronal diseases. Most patients with these deficiencies have shown clinical improvement with oral CoQ10 supplementation especially ...
Comentario: Problemas y mercadeo de las estatinas
(Sociedad Médica de Santiago, 2010)