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HIF involvement in the regulation of rat Sertoli cell proliferation by FSH
(Academic Press Inc Elsevier Science, 2018-08)
The final number of Sertoli cells reached during the proliferative periods determines sperm production capacity in adulthood. It is well known that FSH increases the rate of proliferation of Sertoli cells; however, little ...
Cloning of hif-1alpha and hif-2alpha and mRNA expression pattern during development in zebrafish
(Elsevier, 2007-01)
Hypoxia-inducible factors (HIFs) regulate gene expression in response to hypoxia and in vertebrates they are known to participate in several developmental processes, including angiogenesis, vasculogenesis, heart and central ...
Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
(2021)
Abstract
Background
The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular tone and immune function, and it has ...
Participation of HIFs in the regulation of Sertoli cell lactate production
(Elsevier France-editions Scientifiques Medicales Elsevier, 2017-01)
Hypoxia Inducible Factors (HIFs) are master regulators of glycolytic metabolism. HIFs consist of a constitutive HIFbeta (HIFβ) subunit and a HIFalpha (HIFα) subunit, whose half-life depends on prolyl-hydroxylases activity. ...
Cloning of hif-1 and hif-2 and mRNA expression pattern during development in zebraWsh
(Elsevier B.V., 2006-08-15)
Hypoxia-inducible factors (HIFs) regulate gene expression in response to hypoxia and in vertebrates they are known to participate in several
developmental processes, including angiogenesis, vasculogenesis, heart and central ...
HIF-1α is a protective factor in conditional PHD2-βdeficient mice suffering from severe HIF-2-induced excessive erythropoiesis
(Elsevier, 2013)
Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its transcription factor hypoxia inducible ...
Perfil da expressão de HIF-1α em células linfoides do infiltrado inflamatório peritumoral e intratumoral como marcador prognóstico do carcinoma epidermoide de cavidade oral
(2014-02-21)
O complexo transcricional HIF-1 é responsável por controlar a transcrição de mais de 100 genes envolvidos em resposta celular a hipóxia. A subunidade HIF-1α é estabilizada em condições de hipóxia e dimeriza-se com um a ...
Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1 alpha S-Nitrosylation and Transcriptional Activity in Hypoxia
(MDPI, 2020)
Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...