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Identification, characterization and expression analysis of hepcidin gene in sheep
(Elsevier B.V., 2011-06-01)
Hepcidin is part of the innate immune system, and it plays a central role in the regulation of iron homeostasis. This peptide has been previously characterized in man, non-human primates, rat, mouse, dog, swine, cattle, ...
Cloning, sequencing and expression analysis of the equine hepcidin gene by real-time PCR
(Elsevier B.V., 2010-05-15)
Equine serum or plasma iron concentration drops quickly during inflammation. Accumulation of iron inside macrophages and reduction of the intestinal absorption of this element cause hypoferremia during systemic inflammatory ...
Lipopolysaccharide infusion up-regulates hepcidin mRNA expression in equine liver
(Sage Publications Ltd, 2012-06-01)
Hepcidin has been found to be the key regulator of iron metabolism that leads to hypoferremia during inflammation. Recent work has shown that equine hepcidin is predominantly expressed in the liver of horses. In this study, ...
Lipopolysaccharide infusion up-regulates hepcidin mRNA expression in equine liver
(Sage Publications Ltd, 2012-06-01)
Hepcidin has been found to be the key regulator of iron metabolism that leads to hypoferremia during inflammation. Recent work has shown that equine hepcidin is predominantly expressed in the liver of horses. In this study, ...
Cloning, sequencing and expression analysis of the equine hepcidin gene by real-time PCR
(Elsevier B.V., 2010-05-15)
Equine serum or plasma iron concentration drops quickly during inflammation. Accumulation of iron inside macrophages and reduction of the intestinal absorption of this element cause hypoferremia during systemic inflammatory ...
Identification, characterization and expression analysis of hepcidin gene in sheep
(Elsevier B.V., 2011-06-01)
Hepcidin is part of the innate immune system, and it plays a central role in the regulation of iron homeostasis. This peptide has been previously characterized in man, non-human primates, rat, mouse, dog, swine, cattle, ...
Suppression of plasma hepcidin by venesection during steady-state hypoxia
(Elsevier, 2016)
Hepcidin inhibits iron uptake from the gut and release of iron from macrophages in the reticuloendothelial system. Suppression of plasma hepcidin occurs in lowlanders after ascent to high altitude, reflecting the increased ...
Influence of experimental inflammatory response on hepatic hepcidin gene expression and plasma iron concentration in sheep
(Elsevier B.V., 2011-05-15)
Hepcidin is a highly conserved disulfide-bonded peptide that plays a central role in iron homeostasis. During systemic inflammation, hepcidin up-regulation is responsible for hypoferremia. This study aimed to analyze the ...
Regulation of hepcidin expression at high altitude
(Elsevier, 2012)
Enhanced erythropoietic drive and iron deficiency both influence iron homeostasis through the suppression of the iron regulatory hormone hepcidin. Hypoxia also suppresses hepcidin through a mechanism that is unknown. We ...
Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia
(Wiley, 2017)
Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid-beta (A beta) induces inflammation and oxidative stress, which have ...