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Predicción de péptidos de unión a células eritrocíticas usando herramientas computacionales
(2012)
En la Fundación Instituto de Inmunología de Colombia (FIDIC) existe una estrategia para el diseño de vacunas sintéticas. Ésta se basa en la identificación de fragmentos peptídicos de más o menos 20 aminoácidos provenientes ...
Conserved regions from Plasmodium falciparum MSP11 specifically interact with host cells and have a potential role during merozoite invasion of red blood cells
Despite significant global efforts, a completely effective vaccine against Plasmodium falciparum, the species responsible for the most serious form of malaria, has not been yet obtained. One of the most promising approaches ...
Fine mapping of Plasmodium falciparum ribosomal phosphoprotein PfP0 revealed sequences with highly specific binding activity to human red blood cells
The Plasmodium falciparum P0 ribosomal phosphoprotein (PfP0) was identified for the first time by screening a cDNA expression library of P. falciparum parasites with sera from malaria-immune individuals. Due to its ...
Estudio de las características estructurales del compuesto HA-BP obtenidos por síntesis química y molienda reactiva
(2018-05-03)
RESUMEN:
Este trabajo, tuvo como objetivo el estudio del efecto del bifosfonato BP sobre las características estructurales de la hidroxiapatita HA, al formarse un compuesto HA-BP, así como su evaluación de compatibilidad ...
Identification of peptides with high red blood cell and hepatocyte binding activity in the Plasmodium falciparum multi-stage invasion proteins: PfSPATR and MCP-1
Plasmodium falciparum multi-stage proteins are involved in vital processes for parasite survival, which turns them into attractive targets for studies aimed at developing a fully effective antimalarial vaccine. MCP-1 and ...
Peptides derived from Mycobacterium tuberculosis Rv2301 protein are involved in invasion to human epithelial cells and macrophages
The specific function of putative cut2 protein (or CFP25), encoded by the Rv2301 gene from Mycobacterium tuberculosis H37Rv, has not been identified yet. The aim of this study was to assess some of CFP25 characteristics ...
Binding activity, structure, and immunogenicity of synthetic peptides derived from Plasmodium falciparum CelTOS and TRSP proteins
Several sporozoite proteins have been associated with Plasmodium falciparum cell traversal and hepatocyte invasion, including the cell-traversal protein for ookinetes and sporozoites (CelTOS), and thrombospondin-related ...
Functional, immunological and three-dimensional analysis of chemically synthesisedsporozoite peptides as components of a fully-effective antimalarial vaccine
Our ongoing search for a fully-effective vaccine against the Plasmodium falciparum parasite (causing the most lethal form ofhuman malaria) has been focused on identifying and characterising proteins' amino acid sequences ...
Phi (?) and psi (?) angles involved in malarial peptide bonds determine sterile protective immunity
Modified HABP (mHABP) regions interacting with HLA-DR?1 molecules have a more restricted conformation and/or sequence than other mHABPs which do not fit perfectly into their peptide binding regions (PBR) and do not induce ...
Protective immunity provided by a new modified SERA protein peptide: Its immunogenetic characteristics and correlation with 3D structure
The serine repeat antigen (SERA) protein is a leading candidate molecule for inclusion as a component in a multi-antigen, multi-stage, minimal subunit-based, chemically synthesised anti-malarial vaccine. Peptides having ...