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The iodide-transport-defect-causing mutation R124H: a δ-amino group at position 124 is critical for maturation and trafficking of the Na+/I− symporter
(Company of Biologists, 2013-08)
Na+ /I2 symporter (NIS)-mediated active accumulation of I2 in thyrocytes is a key step in the biosynthesis of the iodine-containing thyroid hormones T3 and T4. Several NIS mutants have been identified as a cause of congenital ...
Prospecting for l-arabinose/d-xylose symporters from Pichia guilliermondii and Aureobasidium leucospermi
(2020-03-01)
With the strong trend toward sustainable technologies, such as the gradual substitution of fossil fuel consumption, improvement in the utilization of sugars from lignocellulosic biomass appears to be an alternative for ...
Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species
(Endocrine Society, 2015)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated ...
Excess iodide downregulates Na+/I− symporter gene transcription through activation of PI3K/Akt pathway
(Elsevier Ireland, 2016-05)
Transcriptional mechanisms associated with iodide-induced downregulation of NIS expression remain uncertain. Here, we further analyzed the transcriptional regulation of NIS gene expression by excess iodide using PCCl3 ...
The Acute Inhibitory Effect of Iodide Excess on Sodium/Iodide Symporter Expression and Activity Involves the PI3K/Akt Signaling Pathway
(Endocrine Society, 2014-03)
Iodide (I−) is an irreplaceable constituent of thyroid hormones and an important regulator of thyroid function, because high concentrations of I− down-regulate sodium/iodide symporter (NIS) expression and function. In ...
The role of LuloPAT amino acid/proton symporters in midgut alkalinization in the sandfly Lutzomyia longipalpis (Diptera – Psychodidae)
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAICB - DEPARTAMENTO DE PARASITOLOGIAUFMG, 2019)
Em fêmeas de Lutzomyia longipalpis, que são os principais vetores de Leishmania infantum nas Américas, a hematofagia é crucial para o desenvolvimento ovariano. O controle do pH no intestino médio durante a digestão do ...
The role of LuloPAT amino acid/proton symporters in midgut alkalinization in the sandfly Lutzomyia longipalpis (Diptera – Psychodidae)
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE PARASITOLOGIAUFMG, 2020-01)
Nas fêmeas de Lutzomyia longipalpis, principais vetores de Leishmania infantum nas Américas, a hematofagia é crucial para o desenvolvimento dos ovários. O controle do pH no intestino médio durante a digestão do sangue é ...
Congenital iodide transport defect: recent advances and future perspectives
(iMedPub Journals, 2016-06)
Iodide is an irreplaceable component of thyroid hormones; therefore, a key requirement for thyroid hormone synthesis is that iodide is actively accumulated in the thyroid. The ability of thyroid follicular cell to concentrate ...