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Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin
(Associação Brasileira de Divulgação Científica, 2006-08-01)
Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone ...
Ghrelin plasma levels in patients with idiopathic short stature
(2011)
Background: Novel molecular insights have suggested that ghrelin may be involved in the pathogenesis of some forms of short stature. Recently, growth hormone secretagogue receptor (GHSR) mutations that segregate with short ...
From growth hormone-releasing peptides to ghrelin: discovery of new modulators of GH secretion
(Sociedade Brasileira de Endocrinologia e Metabologia, 2006-02-01)
Growth hormone (GH)-releasing hormone and somatostatin modulate GH secretion. A third mechanism has been discovered in the last decade, involving the action of GH secretagogues. Ghrelin is a new acylated peptide produced ...
Ghrelina e secretagogos do hormônio de crescimento (GHS): modulação da secreção do hormônio de crescimento e perspectivas terapêuticas
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-07-01)
Growth hormone-releasing hormone (GHRH) and somatostatin modulate growth hormone (GH) secretion. A third mechanism was discovered in the last decade, involving the action of growth hormone secretagogues (GHS). Ghrelin, the ...
Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice
(HOSPITAL CLINICAS, UNIV SAO PAULOSAO PAULO, 2012)
OBJECTIVE: To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormone-releasing ...
The intriguing ligand-dependent and ligand-independent actions of the growth hormone secretagogue receptor on reward-related behaviors
(Elsevier, 2020-01)
The growth hormone secretagogue receptor (GHSR) is a G-protein coupled receptor (GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is evoked by the stomach-derived peptide hormone ...
Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice
(Faculdade de Medicina / USP, 2012)
OBJECTIVE: To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormonereleasing ...
Growth hormone secretagogue receptor constitutive activity impairs voltage-gated calcium channel-dependent inhibitory neurotransmission in hippocampal neurons
(Wiley Blackwell Publishing, Inc, 2018-11)
Key points: Presynaptic CaV2 voltage-gated calcium channels link action potentials arriving at the presynaptic terminal to neurotransmitter release. Hence, their regulation is essential to fine tune brain circuitry. CaV2 ...