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Liver glycogen metabolism during short-term insulin-induced hypoglycemia in fed rats
(JOHN WILEY & SONS LTD, 2008)
The activities of glycogen phosphorylase and synthase during infusions of glucagon, isoproterenol, or cyanide in isolated liver of fed rats submitted to short-term insulin-induced hypoglycemia (IIH) was investigated. A ...
Circadian clock regulation of the glycogen synthase (gsn) gene by WCC is critical for rhythmic glycogen metabolism in Neurospora crassa
(Natl Acad Sciences, 2019-05-21)
Circadian clocks generate rhythms in cellular functions, including metabolism, to align biological processes with the 24-hour environment. Disruption of this alignment by shift work alters glucose homeostasis. Glucose ...
A protein kinase screen of Neurospora crassa mutant strains reveals that the SNF1 protein kinase promotes glycogen synthase phosphorylation
(2014)
Glycogen functions as a carbohydrate reserve in a variety of organisms and its metabolism is highly regulated. The activities of glycogen synthase and glycogen phosphorylase, the rate-limiting enzymes of the synthesis and ...
Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway
(Elsevier Science Inc, 2016-08)
Recently, we have reported that the IL-2-stimulated T cells activate PKCθ in order to phosphorylate the serine residues of αPIX-RhoGEF, and to switch on the Rac1/PYGM pathway resulting in T cell migration and proliferation. ...
Mcardle disease: New insights into its underlying molecular mechanisms
(Molecular Diversity Preservation International, 2019-12)
McArdle disease, also known as glycogen storage disease type V (GSDV), is characterized by exercise intolerance, the second wind phenomenon, and high serum creatine kinase activity. Here, we recapitulate PYGM mutations in ...
SCHIFF-BASES OF PYRIDOXAL 5'-PHOSPHATE AND POLYPEPTIDES CONTAINING L-LYSINE - A KINETIC-STUDY
(ELSEVIER SCIENCE BV, 1991)
The apparent rate constants of formation (k1) and hydrolysis (k2), and the apparent equilibrium constant (K(pH)) of the Schiff bases of pyridoxal 5'-phosphate and poly-L-lysine in different degrees of polymerization have ...
DETERMINATION OF THE RATES OF FORMATION AND HYDROLYSIS OF THE SCHIFF-BASES FORMED BY PYRIDOXAL 5'-PHOSPHATE AND COPOLYPEPTIDES CONTAINING L-LYSINE
(ELSEVIER SCIENCE BV, 1993)
We determined the apparent rate constants of formation (k1) and hydrolysis (k2) of the Schiff bases formed between pyridoxal 5'-phosphate (PLP) and L-lysine and L-alanine copolymers of different compositions, as well as ...
Polymer phosphorylases:clues to the emergence of non-replicative and replicative polymers
(Springer, 2011-12)
Polymer formation is arguably one of the essential factors that allowed the emergence, stabilisation and spread of life on Earth. Consequently, studies concerning biopolymers could shed light on the origins of life itself. ...