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Amplifying immunogenicity of prospective Covid-19 vaccines by glycoengin- eering the coronavirus glycan-shield to present α-gal epitopes
The many carbohydrate chains on Covid-19 coronavirus SARS-CoV-2 and its S-protein form a glycanshield that masks antigenic peptides and decreases uptake of inactivated virus or S-protein vaccines by APC.
Studies on ...
Strategies to develop therapeutic N- and O-hyperglycosylated proteins
(Springer, 2018)
Glycoengineering by N- and/or O-hyperglycosylation represents a procedure to introduce potential sitesfor adding N- and/or O-glycosyl structures to proteins with the aim of producing biotherapeutics withimproved pharmacodynamic ...
Improving bioreactor production of a recombinant glycoprotein in Escherichia coli: Effect of specific growth rate on protein glycosylation and specific productivity
(John Wiley & Sons Inc, 2019-02)
In the last decades bacterial glycoengineering emerged as a new field as the result of the ability to transfer the Campylobacter jejuni N- glycosylation machinery into Escherichia coli for the production of recombinant ...
Química bioortogonal: cuando los organismos vivos se convierten en matraces de reacción
(Pontificia Universidad Católica del Perú, 2023)
Highly glycosylated human alpha interferon: An insight into a new therapeutic candidate
(Elsevier Science, 2010-03)
The type I human interferon alpha (hIFN-α) family consists of small proteins that exert a multiplicity of biological actions including antiviral, antiproliferative and immunomodulatory effects. However, though administration ...
Desarrollo de una tecnología de producción de interferón alfa humano recombinante glicosilado en células eucariontes
(2008-05-26)
El interferón alfa humano comprende una familia de proteínas que bloquean la infección viral e inhiben la proliferación celular. La citoquina producida en bacterias se encuentra aprobada para su uso clínico en el tratamiento ...
Nuevos candidatos terapéuticos para el tratamiento de enfermedades neurodegenerativas.
La eritropoyetina humana (hEPO) es una citoquina glicosilada, cuya función principal es la eritropoyesis. Se han descubierto otras funciones para la hEPO que han expandido las expectativas de su uso clínico a nivel de ...
A bacterial glycoengineered antigen for improved serodiagnosis of porcine brucellosis
(American Society for Microbiology, 2016-06)
Brucellosis is a highly zoonotic disease that affects animals and human beings. Brucella suis is the etiological agent of porcine brucellosis and one of the major human brucellosis pathogens. Laboratory diagnosis of porcine ...
Bifunctional GM-CSF-derived peptides as tools for O-glycoengineering and protein tagging
(Elsevier Science, 2021-02)
Rapid development of effective biotherapeutics has been a concern during the last couple decades. In our work we designed two novel peptide tags, GMOP and mGMOP, derived from the N-terminal region of human granulocyte and ...