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Modulação do sistema glutamatérgico em plaquetas: efeito de metais pesados e organocalcogênios
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2007-01-19)
Research strategies have been developed to characterize parameters in peripheral tissues that might easily be measured in humans as surrogate markers of damage, dysfunction or interactions involving neural targets of ...
Mecanismos de captação e toxicidade do metilmercúrio: Envolvimento do sistema glutamatérgico e do cálcio em fatias e mitocôndrias de ratos.
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2012-01-22)
Methylmercury (MeHg) is a highly toxic environmental contaminant that can be accumulated on several tissues, inducing cellular dysfunction on various organs, especially in the central nervous system (CNS). The mechanisms ...
Avaliação da efetividade da escetamina subcutânea para o tratamento da anedonia em pacientes com episódio depressivo resistente ao tratamento
(Universidade Federal de São Paulo (UNIFESP), 2021)
Anhedonia is a symptom associated with poorer outcomes in depression treatment, including resistance to treatment, greater functional impact and suicidality. Few treatments have proven efficacious to treat anhedonia in ...
Alterações comportamentais e neuroquímicas causadas por compostos orgânicos de selênio
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2006-11-22)
Selenium organic compounds, ebselen and diphenyl diselenide (PhSe)2, are considered mimics of glutathione peroxidase enzyme and present antioxidants and anti-inflammatory properties in different models of brain injury. In ...
Connexin 43 hemichannels and pannexin-1 channels contribute to the α-synuclein-induced dysfunction and death of astrocytes
(John Wiley and Sons Inc., 2019)
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model
(2010)
Quinolinic acid (QA) is an N-methyl-D-aspartate receptor agonist that also promotes glutamate release and
inhibits glutamate uptake by astrocytes. QA is used in experimental models of seizures studying the effects ...
Papel protetor do 2-feniletinil-butilterúrio em modelos de dano cognitivo em camundongos e na apoptose em células humanas
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2013-03-27)
Memory is considered to be a process that has several stages, including acquisition, consolidation and retrieval.
Memory impairment occurs when important synapses are modified. Alzheimer s disease (DA) is the most
common ...