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Liver glucokinase: An overview on the regulatorymechanisms of its activity
(John Wiley & Sons Inc, 2011-01)
Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. ...
Order-Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Glucokinase (GCK) catalyzes the rate-limiting step of glucose catabolism in the pancreas, where it functions as the body's principal glucose sensor. GCK dysfunction leads to several potentially fatal diseases including ...
Three unreported glucokinase (GCK) missense mutations detected in the screening of thirty-two Brazilian kindreds for GCK and HNF1A-MODY
(Elsevier B.V., 2014-11-01)
Thirty-two Brazilian families with MODY phenotype were screened for GCK and HNF1A mutations. GCK mutations were found in 8 families, all patients with mild asymptomatic hyperglycaemia; 3 of them are novel: p.Asp365Asn, ...
MODY 2: Mutation identification and molecular ancestry in a Brazilian family
(2013-01-10)
Maturity Onset Diabetes of the Young (MODY) is a heterogeneous group of genetic diseases characterized by a primary defect in insulin secretion and hyperglycemia, non-ketotic disease, monogenic autosomal dominant mode of ...
MODY 2: Mutation identification and molecular ancestry in a Brazilian family
(2013-01-10)
Maturity Onset Diabetes of the Young (MODY) is a heterogeneous group of genetic diseases characterized by a primary defect in insulin secretion and hyperglycemia, non-ketotic disease, monogenic autosomal dominant mode of ...
Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus
(WILEY, 2009)
Background: Incidental hyperglycemia in children generates concern about the presence of preclinical type I diabetes mellitus (T1DM).
Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus
(WILEY-BLACKWELL PUBLISHING, 2009-09)
Background: Incidental hyperglycemia in children generates concern about the presence of preclinical type I diabetes mellitus (T1DM).
Objective: To genetically evaluate two corm-non forms of maturity-onset diabetes of ...