Nuclear Ca2+ is important for the regulation of several nuclear processes such as gene expression. Localized Ca2+ signals (LCSs) in skeletal muscle fibers of mice have been mainly studied as Ca2+ release events from the ...

Trypanosoma cruzi, the protozoan parasite that causes Chagas’ disease, exhibits peculiar biological features. Among them, the presence of a unique mitochondrion is remarkable. Even though the mitochondrial DNA constitutes ...

The receptors for the second messenger InsP(3) comprise a family of closely related ion channels that release Ca(2+) from intracellular stores, most prominently the endoplasmic reticulum and its extension into the nuclear ...

Postsynaptic Ca2+ signals generated in spines, dendrites, or the soma by neuronal stimulation can reach the nucleus, where they exert a key role in the fast activation of transcription factors and the expression of genes, ...

c-Fos is a well-recognized member of the AP-1 (activator protein-1) family of transcription factors. In addition to this canonical activity, we previously showed that cytoplasmic c-Fos activates phospholipid synthesis ...

La comunicación sinapsis-núcleo es fundamental para la adecuada integración de los estímulos sinápticos que constantemente reciben las neuronas, y que resultan tanto en cambios en la estructura y la función de las espinas ...

RNA splicing has been recognized in recent years as a pivotal player in heart development and disease. The Ca2C/calmodulin dependent protein kinase II delta (CaMKIId) is a multifunctional Ser/Thr kinase family and generates ...