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Neural conditional ablation of the protein tyrosine phosphatase receptor Delta PTPRD impairs gliogenesis in the developing mouse brain cortex
(Frontiers Media SA, 2024)
Neurodevelopmental disorders are characterized by alterations in the development of the cerebral cortex, including aberrant changes in the number and function of neural cells. Although neurogenesis is one of the most studied ...
Sonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases
(2014-03)
The morphogen Sonic Hedgehog (SHH) plays a critical role in the development of
different tissues. In the central nervous system, SHH is well known to contribute to
the patterning of the spinal cord and separation of the ...
Regulation of neurogenesis and gliogenesis of retinoic acid-induced P19 embryonal carcinoma cells by P2X2 and P2X7 receptors studied by RNA interference
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Embryonic carcinoma cells are widely used models for studying the mechanisms of proliferation and differentiation occurring during early embryogenesis. We have now investigated how down-regulation of P2X2 and P2X7 receptor ...
Aspectos morfológicos e histopatológicos da lesão e da regeneração do nervo periférico: uma abordagem ao sistema nervoso somático.
(Universidade Federal de Juiz de Fora - Campus Avançado de Governador ValadaresBrasilICV - Instituto de Ciências da VidaUFJF/GV, 2022)
O efeito neuroprotetor da Espermina em condições de inflamação ocorre via BDNF, ativação do receptor TrkB, CREB e alteração na neurogênese
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2019-06-11)
Lipopolysaccharide (LPS) has been long known to promote neuroinflammation and disrupting memory pathway and neurogenesis. Since spermine, one of the main natural polyamines in the central nervous system, protects from LPS ...
Proliferative hippocampal activity in a group of patients with Rasmussen's encephalitis: Neuronal, glial, and BDNF tissue expression correlations
(Academic Press Inc Elsevier Science, 2018)
Rasmussen's encephalitis (RE) is a rare and devastating unilateral inflammatory brain disease that causes severe and intractable partial epilepsy. It has been shown that epilepsy and subsequent inflammation have deleterious ...
Microglia-precursor cell interactions in health and in pathology
(Instituto de Histología y Embriología "Dr. Mario Burgos", 2018-11)
Until recently, microglia were mainly known as the resident phagocytes of the brain, i.e. the ‘immunological warriors’ of the brain. However, extensive knowledge is being accumulated about the functions of microglia beyond ...
Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds
(2020-01-01)
The high concentrations of free fatty acids as a consequence of obesity and being overweight have become risk factors for the development of different diseases, including neurodegenerative ailments. Free fatty acids are ...