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Determinants of differential functions of galectin-8 on T cells and tumoral cells : interplay of galectin-8 isoforms, integrin and growth factor signaling pathways.
(2014)
Galectins are a subfamily of lectins involved in a variety of cellular processes mainly related with the immune system and cancer. Galectins are secreted through unconventional mechanisms, because they lack a signal peptide, ...
An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2
(De Gruyter, 2012-12)
Polypeptide GalNAc-transferases (ppGalNAc-Ts) are a family of enzymes that catalyze the initiation of mucintype O -glycosylation. All ppGalNAc-T family members contain a common (QXW) 3 motif, which is present in the R-type ...
Glicosilación de tipo 0-GalNAc en el núcleo de células humanas
(2017)
El núcleo es una organela altamente compleja y es considerado una de las estructuras más importantes de las células eucariotas. Su complejidad es un reflejo de dos funciones esenciales que cumple en la célula: una de ellas ...
Papel das Galectinas-1, -3 e -9 em doenças inflamatórias crônicas da pele.
(Universidade Estadual Paulista (Unesp), 2021-09-01)
As respostas imunes que envolvem as inflamações crônicas da pele, tais como psoríase e dermatite, são complexas e evidenciam o desafio no diagnóstico clínico, sendo fundamental o estudo de biomarcadores para melhor definição ...
O papel do epítopo α-Gal (Galα1-3Galβ1-4GlcNAc-R) no diagnóstico sorológico e na infecção experimental pelo Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em ParasitologiaUFMG, 2017-09-11)
The protozoan parasite Trypanosoma cruzi has a cell surface covered by immunogenic
glycoconjugates expressing the α-Gal epitope, which triggers high levels of protective anti-α-
Gal antibodies in infected individuals, ...
Caracterização de epitopos contendo resíduos de alfa-galactopiranosil em Paracoccidioides e outros fungos patogênicos
(Universidade Federal de São Paulo (UNIFESP), 2019-08-29)
The main focus of this work was to find αGal epitopes (terminal α-galactopisyl) in fungi of medical importance, considering that there is little information regarding the possible roles of these glycotopes in pathogenic ...
Functional control of polypeptide GalNAc-transferase 3 through an acetylation site in the C-terminal lectin domain
(De Gruyter, 2017-01)
O-GalNAc glycans are important structures in cellular homeostasis. Their biosynthesis is initiated by members of the polypeptide GalNAc-transferase (ppGalNAc-T) enzyme family. Mutations in ppGalNAc-T3 isoform cause diseases ...