Buscar
Mostrando ítems 1-10 de 25
BRCA1 loss induces GADD153-mediated doxorubicin resistance in prostate cancer
(American Association for Cancer Research, 2011-08)
BRCA1 plays numerous roles in the regulation of genome integrity and chemoresistance. Although BRCA1 interaction with key proteins involved in DNA repair is well known, its role as a coregulator in the transcriptional ...
BRCA1 and p53 regulate critical prostate cancer pathways
(Nature Publishing Group, 2013-09)
Background: Loss or mutations of the BRCA1 gene are associated with increased risk of breast and ovarian cancers and with prostate cancer (PCa) aggressiveness. Previously, we identified GADD153 as a target of BRCA1 protein, ...
Insulina atenúa la respuesta a estrés de retículo endoplásmico en cultivos primarios de cardiomiocitos de ratas noenatas
(Universidad de ChileCyberDocs, 2010)
Diversas condiciones pueden producir estrés en el retículo endoplásmico, tales como la acción de compuestos, como la tapsigargina (TG) y la tunicamicina (TU) o distintas situaciones patológicas como la hipoxia, daño oxidativo ...
Avaliação do efeito anticâncer dos derivados tiazacridínicos LPSF/AC-34 e LPSF/AC-129
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Ciencias Biologicas, 2016)
Proteasome Inhibition Represses Unfolded Protein Response and Nox4, Sensitizing Vascular Cells to Endoplasmic Reticulum Stress-Induced Death
(PUBLIC LIBRARY SCIENCE, 2011)
Background: Endoplasmic reticulum (ER) stress has pathophysiological relevance in vascular diseases and merges with proteasome function. Proteasome inhibition induces cell stress and may have therapeutic implications. ...
Rol de BRCA1 en la regulación de la transcripción en cáncer de próstataBRCA1 role in transcriptional regulation in prostate cancer
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2011)
Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell
(Springer, 2016)
During the last two decades, new insights into proteasome function and its role in several human diseases made it a potential therapeutic target. In this context, Amblyomin-X is a Kunitz-type FXa inhibitor similar to ...
A apoptose induzida pelo anti-inflamatório não esteróide salicilato de sódio requer a participação da proteína cinase gcn2 e o envolvimento de vias do estresse do retículo endoplasmático
(Universidade Federal de Minas GeraisUFMG, 2011-12-20)
Salicylates are non-steroidal anti-inflammatory drugs with the well-known ability to inhibit cyclooxygenase activity, the key enzyme in prostaglandin biosynthesis. The salicylates also induce the phosphorylation of the ...