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Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease
(SPRINGER HEIDELBERG, 2009)
There is evidence of increased systemic expression of active GSK3B in Alzheimer`s disease patients, which apparently is associated with the formation of senile plaques and neurofibrillary tangles. Due to its central role ...
Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer`s disease
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
The disruption of glycogen synthase kinase 3-beta (GSK3B) homeostasis has implications in the pathophysiology of neuropsychiatric disorders, namely Alzheimer`s disease (AD). GSK3B activity is increased within the AD brain, ...
Platelet GSK3B activity in patients with late-life depression: Marker of depressive episode severity and cognitive impairment?
(INFORMA HEALTHCARE, 2011)
Objective. Increased GSK3B activity has been reported as a state marker of major affective episodes in patients with depression and bipolar disorder. No study so far has addressed GSK3B activity in late-life depression. ...
GSK-3 is an RNA polymerase II phospho-CTD kinase
(Oxford University Press, 2020-05)
We have previously found that UV-induced DNA damage causes hyperphosphorylation of the carboxy terminal domain (CTD) of RNA polymerase II (RNAPII), inhibition of transcriptional elongation and changes in alternative splicing ...
Gsk-3 Inhibitors mimic the cardioprotection mediated by ischemic pre- and postconditioning in hypertensive rats
(Hindawi Publishing Corporation, 2013-09)
The aim of this study was to examine the effects of GSK-3 inhibitors compared with PRE and POS in spontaneously hypertensive rats (SHR). Isolated hearts were submitted to the following protocols: IC: 45 min global ischemia ...
GSK-3 beta/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy
(2016)
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated T-cells (NFAT) is associated with the promotion ...
Gsk-3 β inhibitors mimic the cardioprotection mediated by ischemic pre- and postconditioning in hypertensive rats
(Hindawi Publishing Corporation, 2013-10)
The aim of this study was to examine the effects of GSK-3β inhibitors compared with PRE and POS in spontaneously hypertensive rats (SHR). Isolated hearts were submitted to the following protocols: IC: 45 min global ischemia ...
GSK-3β/NFAT Signaling is involved in testosterone-induced cardiac myocyte hypertrophy
(Public Library Science, 2016-12-15)
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated Tcells (NFAT) is associated with the promotion ...