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Redesigning N-glycosylation sites in a GH3 β-xylosidase improves the enzymatic efficiency
(2019-11-14)
Background: β-Xylosidases are glycoside hydrolases (GHs) that cleave xylooligosaccharides and/or xylobiose into shorter oligosaccharides and xylose. Aspergillus nidulans is an established genetic model and good source of ...
Targeted glycoproteomic identification of cancer cell glycosylation
(Oxford Univ Press Inc, 2009-05)
GalMBP is a fragment of serum mannose-binding protein that has been modified to create a probe for galactose-containing ligands. Glycan array screening demonstrated that the carbohydrate-recognition domain of GalMBP ...
The role of glycosyltransferases in colorectal cancer
(MDPI, 2021)
Colorectal cancer (CRC) is one of the main causes of cancer death in the world. Post-translational
modifications (PTMs) have been extensively studied in malignancies due to its relevance in
tumor pathogenesis and therapy. ...
Influence of carbohydrates on the stability and structure of a hyperglycosylated human interferon alpha mutein
(Elsevier Masson, 2010-08)
Protein physical and chemical instability is one of the major challenges in the development of biopharmaceuticals during every step of the process, ranging from production to final delivery. This is particularly applicable ...
Engineering mammalian-specific post-translational modifications in plant-derived proteins: phosphorylation and Mucin-type O-glycosylation as a challenge.
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2018-12-14)
Expression of economically relevant plant-derived recombinant proteins in alternative expression platforms, especially plant expression platforms, has gained significant interest in recent years, due to the possibility to ...
Ethanol Precipitation Of Glycosyl Hydrolases Produced By Trichoderma Harzianum P49p11
(BRAZILIAN SOC CHEMICAL ENGSAO PAULO, 2015)
Identification and characterization of maize Salmon silks genes involved in insecticidal maysin biosynthesis
(American Society of Plant Biologist, 2016-06)
The century-old maize (Zea mays) salmon silks mutation has been linked to the absence of maysin. Maysin is a C-glycosyl flavone that, when present in silks, confers natural resistance to the maize earworm (Helicoverpa zea), ...
Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer
(Cell Press, 2016-06)
Engineering T cells with chimeric antigen receptors (CARs) has demonstrated remarkable success in eradicating hematological malignancies. In this issue of Immunity, June and colleagues demonstrate the broad antitumor ...
Pressurized Liquids Extraction As An Alternative Process To Readily Obtain Bioactive Compounds From Passion Fruit Rinds
(Inst Chemical EngineersRugby, 2016)
Metabolic oligosaccharide engineering of Plasmodium falciparum intraerythrocytic stages allows direct glycolipid analysis by mass spectrometry
(Elsevier Science, 2012-03)
A recent addition to the arsenal of tools for glycome analysis is the use of metabolic labels that allow covalent tagging of glycans with imaging probes. In this work we show that N-azidoglucosamine was successfully ...