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Extrinsic functions of lectin domains in O-N-acetylgalactosamine glycan biosynthesis
(American Society for Biochemistry and Molecular Biology, 2016-12)
Glycan biosynthesis occurs mainly in Golgi. Molecular organization and functional regulation of this process are not well understood. We evaluated the extrinsic effect of lectin domains (β-trefoil fold) of polypeptide ...
Laboratory production and first characterization of purified recombinant human thyrotropin - IPEN
(Sao Paulo: SBBq, 2002, 2014)
Core 1 O-N-acetylgalactosamine (O-GalNAc) glycosylation in the human cell nucleus
(De Gruyter, 2020-08)
Glycosylation is a very frequent post-translational modification in proteins, and the initiation of O-N-acetylgalactosamine (O-GalNAc) glycosylation has been recently described on relevant nuclear proteins. Here we evaluated ...
The inside and outside: topological issues in plant cell wall biosynthesis and the roles of nucleotide sugar transporters
(2016)
The cell wall is a complex extracellular matrix composed primarily of polysaccharides. Noncellulosic polysaccharides, glycoproteins and proteoglycans are synthesized in the Golgi apparatus by glycosyltransferases (GTs), ...
Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism
(2010)
Hemocyanins are copper-containing glycoproteins in some molluscs and arthropods, and their bestknown function is O2 transport. We studied the site of their biosynthesis in the gastropod Concholepas concholepas by using ...
Thyroglobulin structure, function, and biosynthesis.
(Lippincott Williams, 2012)
Thyroglobulin (TG), a homodimeric glycoprotein of 660 kDa (TG 19S), functions as the highly specialized matrix for thyroid hormone biosynthesis and for the storage of the inactive form of thyroid hormones and iodine (1). ...
IL-12 and neutralization of endogenous IL-10 revert the in vitro antigen-specific cellular immunosuppression of paracoccidioidomycosis patients
(2002-07-25)
Treatment of patients with paracoccidioidomycosis is still a challenge. Patients present defective lymphoproliferation and IFN-γ responses to the main Paracoccidioides brasiliensis antigen (gp43), which correlates with ...
IL-12 and neutralization of endogenous IL-10 revert the in vitro antigen-specific cellular immunosuppression of paracoccidioidomycosis patients
(2002-07-25)
Treatment of patients with paracoccidioidomycosis is still a challenge. Patients present defective lymphoproliferation and IFN-γ responses to the main Paracoccidioides brasiliensis antigen (gp43), which correlates with ...