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Protein-glycan interactions in the control of innate and adaptive immune responses
(Nature Publishing Group, 2008-06)
The importance of protein glycosylation in the migration of immune cells throughout the body has been extensively appreciated. However, our awareness of the impact of glycosylation on the regulation of innate and adaptive ...
State of the union: glycobiology and immunology in the Canadian Rockies
(Oxford Univ Press Inc, 2011-05)
This March nearly 150 investigators attended the first international meeting focused solely on the role of glycans within the immune system. This Keystone Symposia meeting entitled “New Frontiers at the Interface of Immunity ...
Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
(Macmillan Publisher Limited, 2009-05)
The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding ...
Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
(Frontiers Media S.A., 2016-03)
Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, ...
Unlocking the secrets of galectins: a challenge at the frontier of glyco-immunology
(Federation of American Societies for Experimental Biology, 2002-05)
Over the last decade, we have witnessed an explosion of information regarding the function of glycoconjugates, carbohydrate-binding proteins, and the elucidation of the sugar code. This progress has yielded not only important ...
Altered Glycosylation Contributes to Placental Dysfunction Upon Early Disruption of the NK Cell-DC Dynamics
(Frontiers Media, 2020-07)
Immune cells [e. g., dendritic cells (DC) and natural killer (NK) cells] are critical players during the pre-placentation stage for successful mammalian pregnancy. Proper placental and fetal development relies on balanced ...
Editorial: Addressing roles for glycans in immunology using chemical biology
(Frontiers Media S.A., 2020-06)
Glycoconjugates, macromolecules containing carbohydrates (glycans) conjugated to proteins or lipids, are a diverse class of biopolymers capable of regulating cell-cell interactions. They are present in a high, natural ...