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Characterization of the actions of AvTx 7 isolated from Agelaia vicina (Hymenoptera : Vespidae) wasp venom on synaptosomal glutamate uptake and release
(Wiley-Blackwell, 2004-01-01)
It has previously been shown that the denatured crude extract of Agelaia vicina wasp venom inhibits glutamate and GABA uptake in rat cerebral cortex synaptosomes. To identify the components responsible for these effects, ...
Glutamate neurotransmission is affected in prenatally stressed offspring
(Pergamon-elsevier Science Ltd, 2015-05)
Previous studies from our laboratory have shown that male adult offspring of stressed mothers exhibited higher levels of ionotropic and metabotropic glutamate receptors than control rats. These offspring also showed ...
NMDA and group I metabotropic glutamate receptors activation modulates substance P release from the arcuate nucleus and median eminence
(Elsevier Ireland, 2006-01)
Glutamate participates in the regulation of secretion of several neuropeptides, including substance P (SP). Glutamate acts through ionotropic (iGluRS) and metabotropic (mGluRS) receptors. We have investigated whether ...
Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine
(Wiley-liss, div John Wiley & Sons Inc., 2018-11)
When activated, microglial cells have the potential not only to secrete typical proinflammatory mediators but also to release the neurotransmitter glutamate in amounts that may promote excitotoxicity. Here, we wished to ...
Gabaergic agonists modulate the glutamate release from frontal cortex synaptosomes of rats with experimental autoimmune encephalomyelitis
(Bentham Science Publishers, 2015-04)
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease that mimics many of the clinical and pathological features of multiple sclerosis. We have previously described a significant diminution ...
Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
(Pergamon-Elsevier Science Ltd, 2005-06)
The proconvulsive effect of the new generation of antidepressants remains controversial. The authors investigated in naïve rats the effect of chronic treatment with fluoxetine (FLX) on the convulsive threshold and on two ...
Cold-induced glutamate release in vivo from the magnocellular region of the paraventricular nucleus is involved in ovarian sympathetic activation
(2010)
We previously reported that centrally-induced sympathetic activation in response to cold stress is associated with a polycystic ovarian condition in rats, and thyrotrophin-releasing hormone (TRH) released locally from the ...
Participation of the GABAergic system on the glutamate release of frontal cortex synaptosomes from Wistar rats with experimental autoimmune encephalomyelitis
(Pergamon-Elsevier Science Ltd, 2011-08)
We previously found that the glutamate release was decreased in synaptosomes from rat cerebral cortex during the development of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis. Various ...
The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels
(2017)
The mesocorticolimbic circuit projects to the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens, among others, and it originates in the dopaminergic neurons of the ventral tegmental area (VTA). The VTA receives ...
Veratridine-induced release of endogenous glutamate from rat brain cortex slices: a reappraisal of the role of calcium
(1988)
The efflux of endogenous glutamate from thin slices of rat brain cortex superfused in vitro with artificial cerebrospinal fluid (ACSF) was studied. Initially, glutamate efflux was very high (2.5 nmol/mg protein/min), ...