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Reduced expression of hippocampal GluN2A-NMDAR increases seizure susceptibility and causes deficits in contextual memory
(Frontiers Media, 2021-04)
N-methyl-D-aspartate receptors are heterotetramers composed of two GluN1 obligatory subunits and two regulatory subunits. In cognitive-related brain structures, GluN2A and GluN2B are the most abundant regulatory subunits, ...
GluN1 and GluN2A NMDA receptor subunits increase in the hippocampus during memory consolidation in the rat
(Frontiers Media S.A., 2017-01)
It is widely accepted that NMDA receptors (NMDAR) are required for learning and memory formation, and for synaptic plasticity induction. We have previously shown that hippocampal GluN1 and GluN2A NMDAR subunits significantly ...
NMDA Receptor Subunits in the Adult Rat Hippocampus Undergo Similar Changes after 5 Minutes in an Open Field and after LTP Induction
(Public Library Science, 2013-02)
NMDA receptor subunits change during development and their synaptic expression is modified rapidly after synaptic plasticity induction in hippocampal slices. However, there is scarce information on subunits expression after ...
NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition
(Hindawi Publishing Corporation, 2017-07)
NMDA ionotropic glutamate receptors (NMDARs) are crucial in activity-dependent synaptic changes and in learning and memory. NMDARs are composed of two GluN1 essential subunits and two regulatory subunits which define their ...
Lack of pannexin 1 alters synaptic GluN2 subunit composition and spatial reversal learning in mice
(Frontiers media SA, 2018)
Long-term potentiation (LTP) and long-term depression (LTD) are two forms of synaptic plasticity that have been considered as the cellular substrate of memory formation. Although LTP has received considerable more attention, ...
Hippocampal NMDA receptors and the previous experience effect on memory
(Elsevier, 2014-09)
N-methyl-D-aspartate receptors (NMDAR) are thought to be responsible for switching synaptic activity specific patterns into long-term changes in synaptic function and structure, which would support learning and memory. ...
Estudos in silico de inibidores alostéricos do domínio amino terminal de receptores NMDA que contenham a subunidade GluN2B
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS, 2022-01-11)
The NMDA receptor is an ionotropic receptor whose main endogenous ligand is glutamate, the
central pore being permeable to Ca2+ ions, and it is usually composed of 4 subunits structurally
similar to each other, usually ...
Envolvimento da subunidade GluN2B do receptor NMDA e dos receptores de adenosina no efeito neuroprotetor e tipo antidepressivo da atorvastatina
(2019)
A depressão maior (DM) é um transtorno de humor severo associado a alterações morfológicas, neuroquímicas e mudanças na sinalização intracelular no Sistema Nervoso Central (SNC). Os fármacos atualmente disponíveis para seu ...