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Glucocorticoid resistance in chronic diseases
(Elsevier Science, 2016-11)
Glucocorticoids are involved in several responses triggered by a variety of environmental and physiological stimuli. These hormones have a wide-range of regulatory effects in organisms. Synthetic glucocorticoids are ...
Effects of methotrexate on the expression of the translational isoforms of glucocorticoid receptors α and β: Correlation with methotrexate efficacy in rheumatoid arthritis patients
(2011)
Objectives: To test the effect of MTX on the expression of glucocorticoid receptor (GR) α and β isoforms AB, C and D in peripheral blood mononuclear cells (PBMCs) in culture, from newly diagnosed RA patients and to evaluate ...
Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus
(Elsevier, 2019-03)
Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine ...
Glucocorticoids decrease Treg cell numbers in lungs of allergic mice
(Elsevier, 2015)
Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4
(American Society of Biochemistry Molecular Biology, 2020)
LPS regulates the expression of glucocorticoid receptor alpha and beta isoforms and induces a selective glucocorticoid resistance in vitro
(Biomed Central Ltd., 2017)
Background: This study was aimed to evaluate the effect of LPS in glucocorticoid receptor (GR) isoforms expression on different cell lines and PBMC from healthy donors in vitro and glucocorticoid sensitivity of PBMC in ...
Expresión de isoformas del receptor de glucocorticoides en pacientes con enfermedades de Vogt-Koyanagi-Harada
(Universidad de Chile, 2014)
El papel del receptor de glucocorticoide en el estrés temprano
En estudios previos se han relacionado las alteraciones funcionales del eje hipotálamohipofisario-adrenal y el estrés temprano; por ejemplo, el aumento en la producción de corticotropina (ACTH) y glucocorticoide como factor ...
El papel del receptor de glucocorticoide en el estrés temprano
En estudios previos se han relacionado las alteraciones funcionales del eje hipotálamohipofisario-adrenal y el estrés temprano; por ejemplo, el aumento en la producción de corticotropina (ACTH) y glucocorticoide como factor ...
Therapeutic utility of glucocorticoids and antihistamines cotreatment. Rationale and perspectives
(Wiley, 2019-12)
Antihistamines and glucocorticoids (GCs) are often used together in the clinic, in several inflammatory-related situations. Even though there is no clear rationale for this drug association, the clinical practice is based ...