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The novel ruthenium-gamma-linolenic complex [Ru(2)(aGLA)(4)Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosis in vitro
(JOHN WILEY & SONS LTD, 2010)
The present study reports the synthesis of a novel compound with the formula [Ru(2)(aGLA)(4)Cl] according to elemental analyses data, referred to as Ru(2)GLA. The electronic spectra of Ru(2)GLA is typical of a mixed valent ...
New mutations in the GLA gene in Brazilian families with Fabry disease
(NATURE PUBLISHING GROUPNEW YORK, 2012-06)
Fabry disease (FD) is an X-linked inborn error of glycosphingolipid catabolism that results from mutations in the alpha-galactosidase A (GLA) gene. Evaluating the enzymatic activity in male individuals usually performs the ...
Caracterização funcional de variantes presentes no gene GLA de pacientes com suspeita de Doença de Fabry
(Universidade Federal de São Paulo, 2023-01-27)
A Doença de Fabry é uma patologia rara causada por variantes presentes no gene GLA, localizado no braço longo do cromossomo X. Variantes patogênicas nesse gene levam a uma atividade nula ou reduzida em diferentes níveis ...
Resolución Nº 0038-2015/CEB-INDECOPI
(Indecopi, 2015-01-27)
Se declara que constituyen barreras burocráticas ilegales las siguientes medidas impuestas por la Municipalidad Distrital de Pueblo Libre: (i) La exigencia de tramitar una autorización para la instalación de infraestructura ...
Variantes no gene GLA e o perfil enzimático da alfagalactosidase a em pacientes com suspeita de Doença de Fabry
(Universidade Federal de São Paulo (UNIFESP), 2019-03-28)
Objective: To analyze a database with molecular and biochemical results of patients with suspected Fabry disease. From these results, to evaluate the pathogenicity of the variants, as well as to carry out the in vitro ...
Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression
(BIOMED CENTRAL LTDLONDON, 2009)
Background: Gamma-linolenic acid is a known inhibitor of tumour cell proliferation and migration in both in vitro and in vivo conditions. The aim of the present study was to determine the mechanisms by which gamma-linolenic ...
Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression
(BMC, 2009-03-17)
Abstract
Background
Gamma-linolenic acid is a known inhibitor of tumour cell proliferation and migration in both in vitro and in vivo conditions. The aim of the present ...
Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression
(2009-03-17)
Abstract
Background
Gamma-linolenic acid is a known inhibitor of tumour cell proliferation and migration in both in vitro and in vivo conditions. The aim of the present study ...