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The intriguing ligand-dependent and ligand-independent actions of the growth hormone secretagogue receptor on reward-related behaviors
(Elsevier, 2020-01)
The growth hormone secretagogue receptor (GHSR) is a G-protein coupled receptor (GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is evoked by the stomach-derived peptide hormone ...
Analysis of Brain Nuclei Accessible to Ghrelin Present in the Cerebrospinal Fluid
(Pergamon-Elsevier Science Ltd., 2013-12-03)
Ghrelin is a stomach-derived peptide hormone that acts in the brain to regulate many important physiological functions. Ghrelin receptor, named the growth hormone secretagogue receptor (GHSR), is present in many brain areas ...
Development of Nonpeptidic Inverse Agonists of the Ghrelin Receptor (GHSR) Based on the 1,2,4-Triazole Scaffold
(American Chemical Society, 2020-09)
GHSR controls, among others, growth hormone and insulin secretion, adiposity, feeding, and glucose metabolism. Therefore, an inverse agonist ligand capable of selectively targeting GHSR and reducing its high constitutive ...
Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse
(Wiley-liss, Div John Wiley & Sons Inc, 2014-11-01)
Growth hormone secretagogue receptor (GHSR) 1a is the only molecularly identified receptor for ghrelin, mediating ghrelin-related effects on eating, body weight, and blood glucose control, among others. The expression ...
Dopamine receptor type 2 (D2R) and ghrelin receptor (GHSR) co-expression alters Ca V 2.2 modulation by G protein signaling cascades
(American Chemical Society, 2019-12)
Voltage-gated calcium channels type 2.2 (CaV2.2) are activated by action potentials at presynaptic terminals, and their calcium current induces neurotransmitter release. In this context, regulating CaV2.2 is critical, and ...
Growth hormone secretagogue receptor constitutive activity impairs voltage-gated calcium channel-dependent inhibitory neurotransmission in hippocampal neurons
(Wiley Blackwell Publishing, Inc, 2018-11)
Key points: Presynaptic CaV2 voltage-gated calcium channels link action potentials arriving at the presynaptic terminal to neurotransmitter release. Hence, their regulation is essential to fine tune brain circuitry. CaV2 ...
Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice
(Pergamon-Elsevier Science Ltd, 2020-09)
Growth hormone secretagogue receptor (GHSR), the receptor for ghrelin, is expressed in key brain nuclei that regulate food intake. The dopamine (DA) pathways have long been recognized to play key roles mediating GHSR effects ...
Evidence supporting a role for constitutive ghrelin receptor signaling in fasting-induced hyperphagia in male mice
(Endocrine Society, 2018-02)
Ghrelin is a potent orexigenic peptide hormone that acts through the growth hormone secretagogue receptor (GHSR), a G protein–coupled receptor highly expressed in the hypothalamus. In vitro studies have shown that GHSR ...