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A Shift in Paradigms: Spatial Genomics Approaches to Reveal Single-Cell Principles of Genome Organization
(Frontiers Media, 2021-11)
The genome tridimensional (3D) organization and its role towards the regulation of key cell processes such as transcription is currently a main question in biology. Interphase chromosomes are spatially segregated into ...
Symbolic Extensions Applied to Multiscale Structure of Genomes
(Kluwer Academic Publishers, 2014)
A genome of a living organism consists of a long string of symbols over a finite alphabet carrying critical information for the organism. This includes its ability to control post natal growth, homeostasis, adaptation to ...
Short-range regulatory chromatin loops in plants
(Wiley Blackwell Publishing, Inc, 2020-04)
In all eukaryotic organisms, gene expression correlates with the condensation state of the chromatin. Highly packed genome regions, known as heterochromatins, are associated with repressed loci, whereas euchromatic regions ...
The topology of genome-scale metabolic reconstructions unravels independent modules and high network flexibility
(2022)
The topology of metabolic networks is recognisably modular with modules weakly connected apart from sharing a pool of currency metabolites. Here, we defined modules as sets of reversible reactions isolated from the rest ...
Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci
(BioMed Central, 2018)
Abstract
Background
The mammalian genome is transcribed into large numbers of long noncoding RNAs (lncRNAs), but the definition of functional lncRNA groups has proven ...
Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci
(BIOMED Central Ltd., 2018)
Background: The mammalian genome is transcribed into large numbers of long noncoding RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, partly due to their low sequence conservation and ...
Chromatin architecture: A new dimension in the dynamic control of gene expression
(Taylor & Francis, 2016-09)
As the most recent evidence of eukaryotic cell complexity, genome architecturehas astounded the scientific community and prompted a variety of technical andcognitive challenges. Several technologies have emerged and evidenced ...
LHP1 Regulates H3K27me3 Spreading and Shapes the Three-Dimensional Conformation of the Arabidopsis Genome
(Public Library of Science, 2016-07)
Precise expression patterns of genes in time and space are essential for proper development of multicellular organisms. Dynamic chromatin conformation and spatial organization of the genome constitute a major step in this ...
Rearrangement-Based Phylogeny Using the Single-Cut-or-Join Operation
(Ieee Computer SocLos AlamitosEUA, 2013)