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Danish type gelsolin-related amyloidosis in a Brazilian family: case reports
(Conselho Brasileiro de Oftalmologia, 2011-08-01)
Familial amyloidosis of the Finnish type (FAF) is an autosomal dominant form of systemic amyloidosis showing marked geographic clustering in Finland. The disease is caused by a point mutation, 654G-A, in the gelsolin gene. ...
Extracellular Galectin-3 Induces Accelerated Oligodendroglial Differentiation Through Changes in Signaling Pathways and Cytoskeleton Dynamics
(Humana Press, 2019-01)
Galectin-3 (Gal-3) is a chimeric protein structurally composed of unusual tandem repeats of proline and short glycine-rich segments fused onto a carbohydrate recognition domain. Our studies have previously demonstrated ...
Elevated hyaluronan and extracellular matrix metalloproteinase inducer levels in women with preeclampsia
(2013-09-11)
Purpose: Preeclampsia (PE) is a specific syndrome of pregnancy clinically identified by hypertension and proteinuria from the 20th week of gestation associated with a systemic inflammatory response and oxidative stress. ...
Elevated hyaluronan and extracellular matrix metalloproteinase inducer levels in women with preeclampsia
(2013-09-11)
Purpose: Preeclampsia (PE) is a specific syndrome of pregnancy clinically identified by hypertension and proteinuria from the 20th week of gestation associated with a systemic inflammatory response and oxidative stress. ...
Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia
(Nature Publishing Group, 2017)
Sepsis is a life-threatening disorder characterized by organ dysfunction and a major cause of mortality worldwide. The major challenge in studying sepsis is its diversity in such factors as age, source of infection and ...
Galectin-3 prospects as a therapeutic agent for multiple sclerosis
(Shenyang Editorial Dept Neural Regeneration Res, 2019-08)
Galectin-3 (Gal-3) in oligodendrocyte (OLG) differentiation:OLGs are the cells in charge of myelination in the central nervoussystem (CNS), allowing rapid conduction of the neuralaction potential and giving trophic support ...
Polycystin-2 (TRPP2) regulation by Ca2+ is effected and diversified by actin-binding proteins
(Cell Press, 2015-05)
Calcium regulation of Ca2+-permeable ion channels is an important mechanism in the control of cell function. Polycystin-2 (PC2, TRPP2), a member of the transient receptor potential superfamily, is a nonselective cation ...