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Persistent double strand break accumulation does not precede cell death in an olaparib-sensitive BRCA-deficient colorectal cancer cell model
(Sociedade Brasileira de Genética, 2019-12-13)
The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired ...
Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution
(Elsevier, 2020)
Exposure to air pollutants is associated with an increased risk of developing Alzheimer's disease (AD). AD pathological hallmarks and cognitive deficits are documented in children and young adults in polluted cities (e.g. ...
Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
(Elsevier, 2018)
Abstract: Radiotherapy is one of the leading treatments for clinical cancer therapy. External beam radiotherapy has been proposed as an adjuvant treatment for patients bearing differentiated thyroid cancer refractory to ...
Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
(Elsevier Ireland, 2018-12)
Radiotherapy is one of the leading treatments for clinical cancer therapy. External beam radiotherapy has been proposed as an adjuvant treatment for patients bearing differentiated thyroid cancer refractory to conventional ...
Effect of Intermittent ELF MF on Umbilical Cord Blood Lymphocytes
(Veterinary and Human Toxicology, 2020-12)
Having recently shown that intermittent extremely low frequency (ELF) magnetic fields (MF) inhibited proliferation of a cancer cell line, we wondered whether such fields could have some effect on normal blood cells. In ...
Aged blood factors decrease cellular responses associated with delayed gingival wound repair
(Public Library Science, 2017)
Aging is a gradual biological process characterized by a decrease in cell and organism functions. Gingival wound healing is one of the impaired processes found in old rats. Here, we studied the in vivo wound healing process ...