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GABAB receptors in neuroendocrine regulation

Lux, Victoria Adela R.; Bianchi, Maria Silvia; Catalano, Paolo Nicolás; Libertun, Carlos (Springer, 2008-09)

Gamma-amino butyric acid (GABA), in addition to being a metabolic intermediate and the main inhibitory neurotransmitter in the synaptic cleft, is postulated as a neurohormone, a paracrine signaling molecule, and a trophic ...

Postnatal development of the endocrine pancreas in mice lacking functional GABAB receptors

Crivello, Martin; Bonaventura, Maria Marta; Chamson-Reig, Astrid; Arany, Edith; Bettler, Bernhard; Libertun, Carlos; Lux, Victoria Adela R. (American Physiological Society, 2013-03-26)

Adult mice lacking functional GABAB receptors (GABAB1KO) have glucose metabolism alterations. Since GABAB receptors (GABABRs) are expressed in progenitor cells, we evaluated islet development in GABAB1KO mice. Postnatal ...

Multiple failures in the lutenising hormone surge generating system in GABAB1KO female mice

Di Giorgio, Noelia Paula; Bizzozzero Hiriart, Marianne; Surkin, Pablo Nicolas; López, Paula V.; Bourguignon, Nadia; Dorfman, Verónica Berta; Bettler, Bernhard; Libertun, Carlos; Lux, Victoria Adela R. (Wiley Blackwell Publishing, Inc, 2019-09)

Female mice lacking GABAB receptors, GABAB1KO, show disrupted oestrous cycles, reduced pregnancies and increased hypothalamic Gnrh1 mRNA expression, whereas anteroventral periventricular/periventricular preoptic nucleus ...

Sex Differences in insulin resistance in GABAB1 knock out mice

Bonaventura, Maria Marta; Rodriguez, D.; Ferreira, M. L.; Crivello, Martin; Repetto, E. M.; Bettler, B.; Libertun, Carlos; Lux, Victoria Adela R. (Elsevier, 2012-11-20)

We have previously demonstrated that the absence of functional GABA B receptors (GABABRs) disturbs glucose homeostasis in GABAB1KO mice. The aim of this work was to extend our studies of these alterations in GABAB1KO mice ...

Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice

Di Giorgio, Noelia Paula; Semaan, Sheila J.; Kim, Joshua; Lopez, Paula Veronica; Bettler, Bernhard; Libertun, Carlos; Lux, Victoria Adela R.; Kauffman, Alexander S. (Endocrine Society, 2014-03)

Kisspeptin, encoded by Kiss1, stimulates reproduction and is synthesized in the hypothalamic anteroventral periventricular and arcuate nuclei. Kiss1 is also expressed at lower levels in the medial amygdala (MeA) and bed ...

Nicotine-induced molecular alterations are modulated by GABAB receptor activity

Varani, Andrés Pablo; Pedrón, Valeria Teresa; Aon, Amira J.; Höcht, Christian; Acosta, Gabriela Beatriz; Bettler, Bernhard; Balerio, Graciela Noemí (Wiley Blackwell Publishing, Inc, 2018-01)

It has been demonstrated that GABAB receptors modulate nicotine (NIC) reward effect; nevertheless, the mechanism implicated is not well known. In this regard, we evaluated the involvement of GABAB receptors on the behavioral, ...

Role of GABAB receptors on morphine antinociception in male and female mice: Pharmacological and genetic approaches

Pedrón, Valeria Teresa; Varani, Andrés Pablo; Bettler, Bernhard; Balerio, Graciela Noemí (Pergamon-Elsevier Science Ltd, 2019-03)

Previous studies in our laboratory showed an interaction between the GABAergic and opioid systems involved in the analgesic effect of baclofen (BAC). Furthermore, it is known that sex differences exist regarding various ...

Lack of functional GABAB receptors alters Kiss1 , Gnrh1 and Gad1 mRNA expression in the medial basal hypothalamus at postnatal day 4

Di Giorgio, Noelia Paula; Catalano, Paolo Nicolás; Lopez, Paula Veronica; Gonzalez, Betina; Semaan, Sheila J.; Lopez, Gabriela Carina; Kauffman, Alexander S.; Rulli, Susana Beatriz; Somoza, Gustavo Manuel; Bettler, Bernhard; Libertun, Carlos; Lux, Victoria Adela R. (Karger, 2013-12-31)

Adult mice lacking functional GABA B receptors (GABA B1 KO) show altered Gnrh1 and Gad1 expressions in the preoptic area-anterior hypothalamus (POA-AH) and females display disruption of cyclicity and fertility. Here ...

Estradiol-dependent and -independent stimulation of KIss1 expression in the amygdala, BNST, and lateral septum of mice

Stephens, Shannon B.Z.; Di Giorgio, Noelia Paula; Liaw, Reanna B.; Parra, Ruby A.; Yang, Jennifer A.; Chahal, Navdeep; Lux, Victoria Adela R.; Kauffman, Alexander S. (Endocrine Society, 2018-09)

Kisspeptin, encoded by Kiss1, activates reproduction by stimulating GnRH neurons. Although most Kiss1 neurons are located in the hypothalamus, smaller Kiss1 populations also reside in the medial amygdala (MeA), bed nucleus ...

Encefalitis autoinmune: experiencia de una serie de casos

Mariño, Nathalie; Triana, Javier; Nieto, Víctor; Paul Vergara, Jean; Silva, Miguel; Palacios, Eduardo (Sociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Salud, 2019-02-25)