Buscar
Mostrando ítems 1-10 de 609
Regulation of GABAA receptors by prolonged exposure to endogenous and exogenous ligands
(Pergamon-Elsevier Science Ltd, 2018-09)
GABAA receptors mediate most of the fast inhibitory transmissions in the central nervous system. These receptors are pentameric complexes that exhibit high structural and pharmacological heterogeneity, as they can be ...
Phosphatidylinositol 4,5-bisphosphate induced flunitrazepam sensitive-GABAA receptor increase in synaptosomes from chick forebrain
(Springer/Plenum Publishers, 2007-06)
The flunitrazepam sensitive-GABAA receptor density was increased by cytochalasins C and D at 37°C suggesting that microfilament depolymerization induces exposure to the radioligand of a GABAA receptor in synaptosomes (Pharm ...
GABA-induced uncoupling of GABA/benzodiazepine site interactions is associated with increased phosphorylation of the GABAA receptor
(Wiley, 2014-08)
The use-dependent regulation of the GABAA receptor occurs under physiological, pathological, and pharmacological conditions. Tolerance induced by prolonged administration of benzodiazepines is associated with changes in ...
Central α- And β-thujone: Similar anxiogenic-like effects and differential modulation on GABAA receptors in neonatal chicks
(Elsevier Science, 2014-03)
The convulsant effects of α-thujone are attributed to inhibitory actions on the GABAA receptor. We investigated, for the first time, the effects of α-thujone or β-thujone administrated centrally on the fear/anxiety behaviour ...
Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
(American Society for Pharmacology and Experimental Therapeutics, 2016-07)
Oxidizing and reducing agents, which are currently involved in cell metabolism and signaling pathways, can regulate fast inhibitory neurotransmission mediated by γ-aminobutyric acid (GABA) receptors in the nervous system. ...
GABA-induced uncoupling of GABA/benzodiazepine site interactions is mediated by increased GABAA receptor internalization and associated with a change in subunit composition
(Elsevier, 2014-01)
Persistent activation of GABAA receptors triggers compensatory changes in receptor function that are relevant to physiological, pathological and pharmacological conditions. Chronic treatment of cultured neurons with GABA ...
Allosteric positive interaction of thymol with the GABA-A receptor in primary cultures of mouse cortical neurons
(Pergamon-Elsevier Science Ltd, 2006-01)
Thymol is a naturally occurring phenolic monoterpene known for its anti-microbial and anti-oxidant properties. It is used in dental practice and in anaesthetic halothane preparations. Recent studies have reported enhanced ...
Structure-activity relationships of neuroactive steroids acting on the GABAA receptor
(Bentham Science Publishers, 2009-12)
The term "neuroactive steroid" (NAS) refers to steroids which, independent of their origin, are capable of modifying neural activities. These steroids positively or negatively modulate the function of members of the ...