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The natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection.
(2013-04-01)
We have previously shown that the subunit 1 of Leishmania amazonensis RPA (LaRPA-1) alone binds the G-rich telomeric strand and is structurally different from other RPA-1. It is analogous to telomere end-binding proteins ...
The hammer and the dance of cell cycle control
Cell cycle checkpoints secure ordered progression from one cell cycle phase
to the next. They are important to signal cell stress and DNA lesions and to
stop cell cycle progression when severe problems occur. Recent work ...
The S phase checkpoint: When the crowd meets at the fork
(Academic Press Ltd - Elsevier Science Ltd, 2005-06)
Accumulation of unrepaired DNA lesions is the biggest threat to genomic stability. DNA damage checkpoints create windows of time that allow the cell to repair assaults on DNA in each phase of the cell cycle. When DNA lesions ...
The natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection.
(2013-04-01)
We have previously shown that the subunit 1 of Leishmania amazonensis RPA (LaRPA-1) alone binds the G-rich telomeric strand and is structurally different from other RPA-1. It is analogous to telomere end-binding proteins ...
Ação das proteínas LMP1 e RPMS1 do vírus de Epstein- Barr (EBV) na regulação de genes codificadores de proteínas de checkpoint imunológico em células humanas cultivadas in vitro
(Universidade Estadual Paulista (Unesp), 2021-10-25)
A maior parcela da população mundial adulta apresenta infecção latente pelo vírus de Epstein-Barr (EBV), reconhecida como potencialmente cancerígena para humanos. Esse vírus é encontrado nas células neoplásicas de virtualmente ...
A review of the pharmacological and therapeutic effects of auraptene
(Blackwell Publishing Inc., 2019)
The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine
(ElsevierPrograma de Estudio y Control de Enfermedades Tropicales (PECET)Ámsterdam, Países Bajos, 2022)
De novo assembly and functional annotation of Myrciaria dubia fruit transcriptome reveals multiple metabolic pathways for L-ascorbic acid biosynthesis
(BioMed Central, 2015)
Background. Myrciaria dubia is an Amazonian fruit shrub that produces numerous bioactive phytochemicals, but is best known by its high L-ascorbic acid (AsA) content in fruits. Pronounced variation in AsA content has been ...