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APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models
(Elsevier Science Inc, 2018-04-20)
Deposition of amyloid-β (Aβ), the proteolytic product of the amyloid precursor protein (APP), might cause neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the direct involvement of APP in the ...
APP signaling in Alzheimer's disease
(Impact Journals, 2018-11)
A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter ...
Wnt-5a/frizzled9 receptor signaling through the Gαo-Gβγ complex regulates dendritic spine formation
(American Society for Biochemistry and Molecular Biology, 2016-09)
Wnt ligands play crucial roles in the development and regulation of synapse structure and function. Specifically, Wnt-5a acts as a secreted growth factor that regulates dendritic spine formation in rodent hippocampal ...
Simulation of chemotactic migration of a crawling cell by finite elements in a two-dimensional framework
(Universidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería MecánicaFacultad de IngenieríaBogotáUniversidad Nacional de Colombia - Sede Bogotá, 2021)
La migración celular es un proceso presente en todas las etapas de la vida que es accionado principalmente por la dinámica del citoesqueleto de actina. Los trabajos experimentales y computacionales han sido clave para ...