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Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis
(2016-01-01)
Tuberculosis (TB) remains a serious health problem responsible to cause millions of deaths annually. The scenario becomes alarming when it is evaluated that the number of new drugs does not increase proportionally to the ...
Leishmanicidal Activities of Novel Synthetic Furoxan and Benzofuroxan Derivatives
(Amer Soc Microbiology, 2014-08-01)
A novel series of furoxan (1,2,5-oxadiazole 2-oxide) (compounds 3, 4a and -b, 13a and -b, and 14a to -f) and benzofuroxan (benzo[c][1,2,5] oxadiazole 1-oxide) (compounds 7 and 8a to -c) derivatives were synthesized, ...
Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity
(Elsevier MassonIssy les Moulineaux, 2014-07)
Hybrid bioisoster derivatives from N-acylhydrazones and furoxan groups were designed with the objective of obtaining at least a dual mechanism of action: cruzain inhibition and nitric oxide (NO) releasing activity. Fifteen ...
In vivo antileishmanial activity and histopathological evaluation in Leishmania infantum infected hamsters after treatment with a furoxan derivative
(2017-11-01)
N-oxide derivatives compounds such as furoxan and benzofuroxan are promising scaffolds for designing of new antileishmanial drugs. A series of furoxan (1,2,5-oxadiazole 2-N-oxide) (compounds 4a-b, and 14a-f) and benzofuroxan ...
Furoxan derivatives demonstrated in vivo efficacy by reducing Mycobacterium tuberculosis to undetectable levels in a mouse model of infection
(2020-10-01)
Objectives: The most recent survey conducted by the World Health Organization described Tuberculosis (TB) as one of the top 10 causes of death and the leading cause of death from a single infectious agent. The increasing ...
Synthesis and biological activity of new hybrids phthalimide-furoxan derivatives useful to treat sickle cell disease symptoms
(Amer Chemical Soc, 2016-08-20)
New antibacterial agents: Hybrid bioisoster derivatives as potential E. coli FabH inhibitors
(Elsevier B.V., 2016-08-15)
The development of resistance to antibiotics by microorganisms is a major problem for the treatment of bacterial infections worldwide, and therefore, it is imperative to study new scaffolds that are potentially useful in ...
Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds to Treat Sickle Cell Disease Symptoms. Part II: Furoxan Derivatives
(Amer Chemical SocWashingtonEUA, 2012)