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Deciphering How HIV‐1 Intersubtype Recombination Shapes Viral Fitness and Disease Progression
(Elsevier, 2015-03)
Extreme genetic variability is the hallmark of HIV‐1 infection and itrepresents a major challenge for antiviral treatment and vaccine development.HIV‐1 group M dominates the global pandemic. This genetic diversity not only ...
Efeitos do tratamento com ivermectina na evolução de Dengue virus durante a alternância de hospedeiro
(Florianópolis, SC, 2021-08-22)
As doenças virais são um grande problema de saúde pública, e ainda são pouco
conhecidas as dinâmicas entre patógenos e hospedeiros que causam essas doenças. Sem
esse conhecimento, o desenvolvimento de vacinas e tratamento ...
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil
(Public Library Science, 2018-05-01)
The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In Sao Jose do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the ...
Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells
(Public Library of Science, 2017-03)
The Flavivirus genus includes a large number of medically relevant pathogens that cycle between humans and arthropods. This host alternation imposes a selective pressure on the viral population. Here, we found that dengue ...
Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs
(Public Library of Science, 2018-01)
Rapid antigenic evolution enables the persistence of seasonal influenza A and B viruses in human populations despite widespread herd immunity. Understanding viral mechanisms that enable antigenic evolution is critical for ...
Synergistic interactions between the NS3(hel) and E proteins contribute to the virulence of Dengue Virus Type 1
(Public Library of Science, 2018)
Evolución del virus de hepatitis B: Análisis de mecanismos involucrados en el establecimiento y progresión de la infección viral
(2017-12-28)
El virus de hepatitis B (HBV), debido a su estructura poblacional de cuasiespecie, circula como un conjunto de variantes genéticamente relacionadas que evolucionan a lo largo de la infección crónica. La evolución de la ...
Gene expression in primary hemocyte culture of the Pacific white shrimp Penaeus vannamei infected with different white spot syndrome virus (WSSV) strains
(Pontificia Universidad Católica de Valparaíso, 2022)