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The ferryl generation by fenton reaction driven by catechol
(2023)
The Fenton and Fenton-like reactions are based on the decomposition of hydrogen peroxide catalyzed by Fe(II), primarily producing highly oxidizing hydroxyl radicals (HO∙). While HO∙ is the main oxidizing species in these ...
Evidence for a ferryl intermediate in a heme-based dioxygenase
(National Academy of Sciences, 2009-09)
In contrast to the wide spectrum of cytochrome P450 monooxygenases, there are only 2 heme-based dioxygenases in humans: tryptophan dioxygenase (hTDO) and indoleamine 2,3-dioxygenase (hIDO). hTDO and hIDO catalyze the same ...
The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies
(Springer, 2010-08)
Tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) are two heme-containing enzymes which catalyze the conversion of L-tryptophan to N-formylkynurenine (NFK). In mammals, TDO is mostly expressed in liver and ...
Myoglobin-H(2)O(2) catalyzes the oxidation of beta-ketoacids to alpha-dicarbonyls: Mechanism and implications in ketosis
(ELSEVIER SCIENCE INC, 2011)
Acetoacetate (AA) and 2-methylacetoacetate (MAA) are accumulated in metabolic disorders such as diabetes and isoleucinemia. Here we examine the mechanism of AA and MAA aerobic oxidation initiated by myoglobin (Mb)/H(2)O(2). ...
Molecular basis for the substrate stereoselectivity in tryptophan dioxygenase
(American Chemical Society, 2011-11-23)
Tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) are the only two heme proteins that catalyze the oxidation reaction of tryptophan (Trp) to Nformylkynurenine.<br />While human IDO is able to oxidize both ...
Iron and Its Catalytic Properties on Radical Generation: Role of chelators on the labile iron pool (LIP)
(Wiley, 2019)
Iron (Fe) is an essential element for the growth and well-being of almost all living organisms as it is involved in many biological functions since by varying the ligands to which it is coordinated. Fe has access to a wide ...
The Underlying Mechanism of HNO Production by the Myoglobin-Mediated Oxidation of Hydroxylamine
(American Chemical Society, 2020-05)
Azanone (HNO, nitroxyl) is a highly reactive molecule that, in the past few years, has drawn significant interest because of its pharmacological properties. However, the understanding of how, when, and where endogenous HNO ...
Biorecognition of hydrogen peroxide using a novel electrochemical platform designed with Glossoscolex paulistus giant hemoglobin
(2022-01-01)
The giant extracellular hemoglobin of the annelid Glossoscolex paulistus (HbGp; 3.6 MDa) is a valuable and underexplored supramolecular hemoprotein system for the biorecognition of reactive oxygen species. In this work, ...
Myoglobin-H2O2 catalyzes the oxidation of beta-ketoacids to alpha-dicarbonyls: Mechanism and implications in ketosis
(Elsevier B.V., 2011-08-01)
Acetoacetate (AA) and 2-methylacetoacetate (MAA) are accumulated in metabolic disorders such as diabetes and isoleucinemia. Here we examine the mechanism of AA and MAA aerobic oxidation initiated by myoglobin (Mb)/H2O2. ...