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Physiological focus on the erythropoietin–hepcidin–ferroportin axis
(Natl Research Council Canada-n R C Research Press, 2013-05)
To analyze the interconnection between erythropoiesis and iron metabolism, one of the issues raised in this study was to know iron bioavailability under physiopathological conditions. Our aim was to understand the functional ...
Immunolocalization of Ferroportin in Healthy and Anemic Mice
(Histochemical Society, 2009-01-15)
Ferroportin (FPN), the only iron exporter identified to date, participates in iron release from enterocytes and macrophages, regulating its absorption and recycling. We used a murine model of experimental hemolytic anemia ...
Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters dmt1 and ferroportin 1
(AMER PHYSIOLOGICAL SOC, 2010)
Hepcidin inhibits apical iron uptake in intestinal cells
(2007)
Hepcidin (Hepc) is considered a key mediator in iron trafficking. Although the mechanism of Hepc action in macrophages is fairly well established, much less is known about its action in intestinal cells, one of the main ...
Regulatory mechanisms of intestinal iron absorption - uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis
(Wiley, 2010)
Knowledge on the intestinal iron transport process and the regulation of body iron stores has greatly increased during the last decade. The liver, through the sensing of circulating iron, is now recognized as the central ...
Iron Regulation in Elderly Asian Elephants (Elephas maximus) Chronically Infected With Mycobacterium tuberculosis
(Frontiers Media, 2020)
Restriction of nutrients to pathogens (nutritional immunity) is a critical innate immune response mechanism that operates when pathogens such as Mycobacterium tuberculosis have the potential to evade humoral immunity. ...
The dopamine metabolite aminochrome inhibits mitochondrial complex i and modifies the expression of iron transporters DMT1 and FPN1
(2012)
Hallmarks of idiopathic and some forms of familial Parkinson's disease are mitochondrial dysfunction, iron accumulation and oxidative stress in dopaminergic neurons of the substantia nigra. There seems to be a causal link ...