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Antidepressant-relevant behavioral and synaptic molecular effects of long-term fasudil treatment in chronically stressed male rats
(Elsevier, 2020)
Several lines of evidence suggest that antidepressant drugs may act by modulating neuroplasticity pathways in
key brain areas like the hippocampus. We have reported that chronic treatment with fasudil, a Rho-associated
protein ...
Fasudil, un inhibidor de rock, previene las alteraciones conductuales producidas por estrés de restricción de movimiento en un modelo animal de depresión
(Universidad de Chile, 2011)
El estrés psicosocial está relacionado con patologías psiquiátricas como la depresión, la
cual se caracteriza por el deterioro cognitivo y trastornos morfológicos como el
acortamiento de espinas dendríticas y la ...
The ROCK inhibitor fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus
(Oxford University Press, 2017-04-01)
Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply ...
The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus
(Oxford University Press, 2017-04)
Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply ...
Mechanisms of favorable effects of Rho kinase inhibition on myocardial remodeling and systolic function after experimental myocardial infarction in the rat
(2016)
Objective:
The objective of this study was to determine the molecular mechanisms by which cardiac Rho-associated coiled-coil containing protein kinase (ROCK) activation after myocardial infarction (MI) does intervene in ...
Factores transcripcionales Smad2/3 y vía RhoA/ROCK en la hipertensión arterial experimental por sobrecarga de volumen
(Universidad de ChileCyberDocs, 2010)
La hipertensión arterial es uno de los factores de riesgo cardiovascular más
importante en todo el mundo industrializado. En las últimas décadas, la vía de
señalización RhoA/ROCK ha mostrado tener un rol clave en la ...