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Avaliações imunogenéticas do desenvolvimento de anticorpos inibidores do fator VIII na hemofilia A
(Universidade Federal de Minas GeraisUFMG, 2010-04-19)
Hemophilia A (HA) is a coagulopaty with hereditary transmission linked to Xchromosome resulting in a deficiency or a defect in coagulation factor VIII (FVIII). Subjects with this coagulopaty need constant FVIII infusions ...
Cytokine profile and FVIII inhibitors development in haemophilia A
(Blackwell Science, 2018)
A flow cytometry evaluation of anti-FVIII antibodies: Correlation with ELISA and Bethesda assay
(Wiley Blackwell Publishing, Inc, 2011-03)
In this study, we describe a flow cytometry (FC) system for detecting antibodies to factor VIII (FVIII) and compare its results with those of enzyme-linked immunosorbent assay (ELISA) that detects both inhibitory (I-Ab) ...
Production of human factor VIII-FL in 293T cells using the bicistronic MGMT(P140K)-retroviral vector
(FUNPEC-EDITORARIBEIRAO PRETO, 2012)
Hemophilia A is the most common X-linked bleeding disorder; it is caused by deficiency of coagulation factor VIII (FVIII). Replacement therapy with rFVIII produced from human cell line is a major goal for treating hemophilia ...
IgG subclasses of FVIII inhibitors in an argentine cohort of severe hemophilia A patients: Analysis by flow cytometry
(Wiley Blackwell Publishing, Inc, 2017-06)
FVIII inhibitors consist of a polyclonal population of antibodies. Previous studies have demonstrated different distribution of IgG subclasses. IgG4 was associated to high level of FVIII inhibitors and failure of Immune ...
Genetic Variations In Sites Of Affinity Between Fviii And Lrp1 Are Not Associated With High Fviii Levels In Venous Thromboembolism
(NATURE PUBLISHING GROUPLONDON, 2015)