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The paradoxical signals of two TrkC receptor isoforms supports a rationale for novel therapeutic strategies in ALS

Brahimi, Fouad; Maira, Mario; Barcelona, Pablo Federico; Galan, Alba; Aboulkassim, Tahar; Teske, Katrina; Rogers, Mary Louise; Bertram, Lisa; Wang, Jing; Yousefi, Masoud; Rush, Robert; Fabian, Marc; Cashman, Neil; Saragovi, H. Uri (Public Library of Science, 2016-10)

Full length TrkC (TrkC-FL) is a receptor tyrosine kinase whose mRNA can be spliced to a truncated TrkC.T1 isoform lacking the kinase domain. Neurotrophin-3 (NT-3) activates TrkC-FL to maintain motor neuron health and ...