Buscar
Mostrando ítems 1-10 de 52
FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system
(Faculdade de Medicina / USP, 2013-07-01)
OBJECTIVE: Available chemotherapy presents poor control over the development of metastatic melanoma. FTY720 is a compound already approved by the Food and Drug Administration for the treatment of patients with multiple ...
Changes in lymphocyte phenotype and increased skin allograft survival after FTY720+FK506 therapy
(Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2008-01-01)
The development of new drugs to be associated with calcineurin inhibitors and promote additional immunosuppression with fewer side effects is the goal in transplantation. FTY720 is a new synthetic compound which presents ...
TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720
(ELSEVIER SCIENCE BV, 2011)
Ischemia and reperfusion injury (IR) is an antigen independent inflammatory process that causes tissue damage. After IR, kidneys up-regulate leukocyte adhesion molecules and toll-like receptors (TLRs). Moreover, injured ...
The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection
(HOSPITAL CLINICAS, UNIV SÃO PAULOSÃO PAULO, 2012-08)
OBJECTIVES: FTY720 modulates CD4(+)T cells by the augmentation of regulatory T cell activity, secretion of suppressive cytokines and suppression of IL-17 secretion by Th17 cells. To further understand the process of graft ...
FTY720 and lung tumor development
(Elsevier B.V., 2009-06-01)
FTY720 has been shown to prevent cancer development in experimental models but there is no report whether this beneficial effect is associated with the time point of the drug administration. Lung adenoma was induced in ...
Correlação da farmacocinética(FC) e farmacodinâmica (FD) do imunossupressor FTY720 em transplantados renais
(Universidade Federal de São Paulo (UNIFESP), 2004)
FTY720 e uma droga imunomoduladora de linfocitos que induz linfopenia no sangue periferico. A relacao entre a dose ou concentracao sanguinea do FTY720 e da linfopenia no sangue periferico ainda nao esta bem elucidada. O ...
Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients
(Associação Brasileira de Divulgação Científica, 2005-05-01)
FTY720 is a new and effective immunosuppressive agent, which produces peripheral blood lymphopenia through a lymphocyte homing effect. We investigated the relationship between the dose of FTY720 or blood concentration ...
Evaluation of Experimental Autoimmune Uveitis in Mice Treated with FTY720
(ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010)
PURPOSE. FTY720 (fingolimod) is an immunomodulatory drug capable of preventing T-cell migration to inflammatory sites by binding to and subsequently downregulating the expression of sphingosine-1 phosphate receptor 1 ...
Evaluation of Experimental Autoimmune Uveitis in Mice Treated with FTY720
(Assoc Research Vision Ophthalmology Inc, 2010-05-01)
PURPOSE. FTY720 (fingolimod) is an immunomodulatory drug capable of preventing T-cell migration to inflammatory sites by binding to and subsequently downregulating the expression of sphingosine-1 phosphate receptor 1 ...
FTY720 in combination with cyclosporine - an analysis of skin allograft survival and renal function
(Elsevier B.V., 2006-12-20)
Acute and chronic nephrotoxicity caused by CsA Continuous administration impair kidney allograft survival. Several clinical and experimental protocols have shown benefits to the kidney after decreasing CsA dose, withdrawing ...