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Reactive oxygen species and extracellular signal-regulated kinase 1/2 mediate hexachlorobenzene-induced cell death in FRTL-5 rat throyd cells
(Oxford University Press, 2013-05-24)
Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. We have previously shown that chronic HCB exposure triggers apoptosis in rat thyroid follicular cells. This study was carried ...
Comparative effects of transforming growth factor beta isoforms on redox metabolism in thyroid cells
(Elsevier Ireland, 2017-10)
Introduction: Transforming growth factor beta (TGF-β) regulates thyroid function and growth. However, tumoral thyroid cells became resistant to this factor as they undifferentiated. Little is known about the effects of ...
Hexachlorobenzene induces TGF-β1 expression, which is a regulator of p27 and cyclin D1 modifications
(Elsevier, 2014-10)
Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. In this study we have demonstrated that HCB induced loss of cell viability and alterations in cell cycle regulation in FRTL-5 ...
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
(Associação Brasileira de Divulgação Científica, 2001-02-01)
Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently ...
CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells
(Company of Biologists, 2017-12-15)
Many secretory cells increase the synthesis and secretion of cargo proteins in response to specific stimuli. How cells couple increased cargo load with a coordinate rise in secretory capacity to ensure efficient transport ...
Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species
(Endocrine Society, 2015)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated ...
Rab1b overexpression modifies Golgi size and gene expression in HeLa cells and modulates the thyrotrophin response in thyroid cells in culture
(American Society for Cell Biology, 2013-01)
Rab1b belongs to the Rab-GTPase family that regulates membrane trafficking and signal transduction systems able to control diverse cellular activities, including gene expression. Rab1b is essential for endoplasmic ...
2-iodohexadecanal Inhibits thyroid cell growth in part through the induction of let-7f microRNA
(Elsevier Ireland, 2015)
Protection against radiation-induced damage of 6-propyl-2-thiouracil (PTU) in thyroid cells
(Radiation Research Soc, 2012-11)
Many epidemiologic studies have shown that the exposure to high external radiation doses increases thyroid neoplastic frequency, especially when given during childhood or adolescence. The use of radioprotective drugs may ...