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Evolución del mecanismo de intercambio de segmentos en la subfamilia FoxP de factores de transcripción humanos
(Universidad de Chile, 2021)
Las proteínas Fox son una familia de factores de transcripción cuyo dominio de unión a ADN existe canónicamente como monómeros en solución. Sin embargo, las estructuras de FoxP2 y FoxP3, dos proteínas que son miembros de ...
Transcriptional Enhancers in the FOXP2 Locus Underwent Accelerated Evolution in the Human Lineage
(Oxford University Press, 2019-08)
Unique human features such as complex language are the result of molecular evolutionary changes that modified developmental programs of our brain. The human-specific evolution of the forkhead box P2 (FOXP2) gene coding ...
Expresión de foxp3 en células tumorales y su implicación en el pronóstico del cáncer
El factor de transcripción FOXP3, característico de las células T reguladoras (Tregs), se ha encontrado recientemente expresado por células tumorales de diferentes tipos de cáncer. Distintos estudios han reportado que la ...
Reduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells and diminished FOXP3 expression in patients with Common Variable Immunodeficiency: A link to autoimmunity?
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)
Common Variable Immunodeficiency (CVID) is a primary immunodeficiency disease characterized by defective immunoglobulin production and often associated with autoimmunity. We used flow cytometry to analyze CD4(+)CD25(HIGH)FOXP3(+) ...
Expresión de FOXP3 en linfomas de células T: estudio de 47 casos en el Hospital Edgardo Rebagliati Martins, EsSalud, Lima, Perú
(Colegio Médico del Perú, 2009)
Avaliação da frequência de genótipos polimórficos em genes codificadores para FOXP3 e sua associação com as diferentes formas clínicas da Doença de Chagas
(Universidade Federal de Minas GeraisUFMG, 2012-07-09)
The identification of the CD4+CD25high FOXP3+ subset and of its role as regulatory T cells (TREG) has been the object of intense studies due to the putative critical role of these cells in maintaining self-tolerance, as ...
The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
(Rockefeller University Press, 2020)