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Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1
(Elsevier, 2020)
Cardiac fibroblasts (CFs) are necessary to maintain extracellular matrix (ECM) homeostasis in the heart. Normally, CFs are quiescent and secrete small amounts of ECM components, whereas, in pathological conditions, they ...
The role of forkhead box 1 (FOXO1) in the immune system: Dendritic cells, T cells, B cells, and hematopoietic stem cells
(2017-01-01)
Forkhead box-O (FOXO) transcription factors have a fundamental role in the development and differentiation of immune cells. FOXO1 and FOXO3 are FOXO members that are structurally similar and bind to the same conserved ...
FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
(Nature, 2020)
Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and ...
PTEN and FOXO3 expression in the prenatal and postnatal human ovary
(Springer/Plenum Publishers, 2020-05)
Purpose: The objective of this study was to analyse the expression and cellular localization of FOXO3, pFOXO3 and PTEN throughout human ovary development both before and after birth. Methods: Foetal, pubertal and adult ...
Maternal diabetes induces FoxO1 and connexin 43 alterations in the heart of the developing embryo
(Elsevier, 2019)
Background: Maternal diabetes affects the embryonic, fetal and perinatal development and programs metabolic and cardiovascular alterations in the adult offspring. We recently reported cardiovascular alterations related to ...
Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases
(Elsevier, 2018-06)
Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic ...
FoxO3a nuclear localization and its association with beta-catenin and Smads in IFN-alfa-treated hepatocellular carcinoma cell lines
(Mary Ann Liebert Inc, 2014-11)
Interferon-a2b (IFN-a2b) reduces proliferation and increases apoptosis in hepatocellular carcinoma cells by decreasing b-catenin/TCF4/Smads interaction. Forkhead box O-class 3a (FoxO3a) participates in proliferation and ...
Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans
(WILEY, 2009)
P>The methionine sulfoxide reductase system has been implicated in aging and protection against oxidative stress. This conserved system reverses the oxidation of methionine residues within proteins. We analyzed one of the ...
Extracellular ATP regulates FoxO family of transcription factors and cell cycle progression through PI3K/Akt in MCF-77 cells
(Elsevier, 2013-09)
Background: Forkhead Box-O (FoxO) transcription factors regulate the expression of many genes involved in suppression. Released nucleotides can regulate intracellular signaling pathways through membrane-bound purinergic ...
Caracterización de las funciones del factor de transcripción FOXO1 asociadas a la remodelación del tejido conectivo gingival: implicancias en el envejecimiento
(2021)
Introducción/Objetivo: La reparación de heridas está dirigida por múltiples factores de
transcripción. Durante la reparación de heridas se activa el factor de transcripción Forkhead Box
O 1 (FOXO1). El aumento del factor ...