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The fork and the kinase: A DNA replication tale from a CHK1 perspective
(Elsevier Science, 2015-01)
Replication fork progression is being continuously hampered by exogenously introduced and naturally occurring DNA lesions and other physical obstacles. Checkpoint kinase 1 (Chk1) is activated at replication forks that ...
Current understanding of RAD52 functions: Fundamental and therapeutic insights
(Molecular Diversity Preservation International, 2020-03)
In this Special Issue, we would like to focus on the various functions of the RAD52 helicase-like protein and the current implications of such findings for cancer treatment. Over the last few years, various laboratories ...
The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii
(Frontiers in Bioscience, 2016-05)
Toxoplasma gondii is an apicomplexan parasite of medical and veterinary importance which causes Toxoplasmosis in humans. Great effort is currently being devoted towards the identification of novel drugs capable of targeting ...
Evaluation of ATM Kinase inhibitor KU-55933 as potential anti-Toxoplasma gondii agent
(Frontiers Media S.A., 2019-02)
Toxoplasma gondii is an apicomplexan protozoan parasite with a complex life cycle composed of multiple stages that infect mammals and birds. Tachyzoites rapidly replicate within host cells to produce acute infection during ...
Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome
(Elsevier, 2014-02)
Ultraviolet (UV)-induced DNA damage are removed by nucleotide excision repair (NER) or can be tolerated by specialized translesion synthesis (TLS) polymerases, such as Polη. TLS may act at stalled replication forks or ...
Complex rearrangements in patients with duplications of MECP2 can occur by fork stalling and template switching
(OXFORD UNIV PRESS, 2009)
Duplication at the Xq28 band including the MECP2 gene is one of the most common genomic rearrangements identified in neurodevelopmentally delayed males. Such duplications are non-recurrent and can be generated by a ...
Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing
(Nature Publishing Group, 2019-06)
The effectiveness of checkpoint kinase 1 (Chk1) inhibitors at killing cancer cells is considered to be fully dependent on their effect on DNA replication initiation. Chk1 inhibition boosts origin firing, presumably limiting ...
Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks
(Public Library of Science, 2016-01-14)
Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks ...
Estudio hidrológico de la cuenca La Pastoría, Michoacán, región Tierra Caliente
(Universidad Michoacana de San Nicolás de Hidalgo, 2011-08)
Determining a hydrology is vital in generating hydroelectric projects such as warehouses, dams, protective works, bridges, sewers, among others, good hydrology allows not about designing structures, since any structure is ...
Caracterización estructural del promotor del gen Ehrad54 y análisis de la expresión y localización celular de la proteína Ehrad54 de entamoeba histolytica en respuesta al daño al DNA
(2009-03-05)
RESUMEN: La Recombinación Homóloga (RH) además de ser el mecanismo mediante el cual se logra la variabilidad genética durante la replicación del DNA, también es un mecanismo altamente eficiente para la reparación del mismo, ...