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Phosphorylation of Ryanodine Receptors
(Sociedad de Biología de Chile, 2004)
Neuroregenerative and neuroprotective actions of immunophilin ligands in murine models
(Fundación Revista Medicina, 2017)
Immunophilins (IMMs) are a family of intracellular proteins that bind immunosuppressive drugs. They are referred to as FK506-binding proteins (FKBPs) when they bind FK506, and cyclophilins (CyPs) when they bind cyclosporine ...
Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi
(Springer, 2018)
Chagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator ...
Subcellular rearrangement of Hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth
(Wiley, 2010-11)
FKBP51 and FKBP52 (FK506-binding protein 51 and 52) are tetratricopeptide repeat-domain immunophilins belonging to the tetratricopeptide-protein•hsp90•hsp70•p23 heterocomplex bound to steroid receptors. Immunophilins are ...
NMR assignments of the FKBP-type PPIase domain of FKBP42 from Arabidopsis thaliana
(Springer, 2012-09)
The Atfkbp42 gene is associated with reduced and disoriented growth of Arabidopsis thaliana. Resonance assignments are reported for the FKBP-type PPIase domain of AtFKBP42. Signal intensities reveal an additional structure ...
Proof that the high molecular weight immunophilin FKBP52 mediates the in vivo neuroregenerative effect of the macrolide FK506
(Pergamon-Elsevier Science Ltd, 2020-12)
The immunosuppressant drug FK506 (or tacrolimus) is a macrolide that binds selectively to immunophilins belonging to the FK506-binding protein (FKBP) subfamily, which are abundantly expressed proteins in neurons of the ...
Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)
(Elsevier, 2011-08)
The large FK506-binding protein FKBP52 has been characterized as an important positive regulator of androgen, glucocorticoid and progesterone receptor signaling pathways. FKBP52 associates with receptor-Hsp90 complexes and ...