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Analysis of the functional compatibility of SIV capsid sequences in the context of the FIV gag precursor
(Public Library of Science, 2017-05)
The formation of immature lentiviral particles is dependent on the multimerization of the Gag polyprotein at the plasma membrane of the infected cells. One key player in the virus assembly process is the capsid (CA) domain ...
Lentiviral Gag assembly analyzed through the functional characterization of chimeric simian immunodeficiency viruses expressing different domains of the feline immunodeficiency virus capsid protein e114299
(Public Library of Science, 2014-12)
To gain insight into the functional relationship between the capsid (CA) domains of the Gag polyproteins of simian and feline immunodeficiency viruses (SIV and FIV, respectively), we constructed chimeric SIVs in which the ...
Structural elements in the Gag polyprotein of feline immunodeficiency virus involved in Gag self-association and assembly
(Society for General Microbiology, 2014-09)
The Gag polyprotein of feline immunodeficiency virus (FIV) assembles at the plasma membrane of the infected cells. We aimed to identify the FIV Gag domains that interact and promote Gag multimerization. To do this we ...
In vitro assembly of the feline immunodeficiency virus Gag polyprotein
(Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación, 2010)
The retroviral Gag protein is the only viral product that is necessary for the assembly of virions in mammalian cells. We have established an in vitro assembly system to study the assembly properties of purified feline ...
Structural elements in the Gag polyprotein of feline immunodeficiency virus involved in Gag self-association and assembly
(Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación, 2014)
The Gag polyprotein of feline immunodeficiency virus (FIV) assembles at the plasma membrane of the infected cells. Since the FIV Gag domains whose interaction promotes Gag multimerization have not been identified, we ...
The Conserved Tyr176/Leu177 motif in the alpha-Helix 9 of the feline immunodeficiency virus capsid protein is critical for gag particle assembly
(Multidisciplinary Digital Publishing Institute, 2019-09-04)
The capsid domain (CA) of the lentiviral Gag polyproteins has two distinct roles during virion morphogenesis. As a domain of Gag, it mediates the Gag–Gag interactions that drive immature particle assembly, whereas as a ...
Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses
(MDPI, 2014-01)
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis. Therefore, Env incorporation into the ...
Understanding the Process ofEnvelope Glycoprotein Incorporation into Virions in Simian and Feline Immunodeficiency Viruses
(Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación, 2014)
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting
with specific receptors present at the cell surface, thereby determining viral tropism and
pathogenesis. Therefore, Env incorporation into ...
Aspectos epidemiológicos, clínicos y de diagnóstico del ViLeF y VIF : una revisión actualizada
(Universidad Pedagógica y Tecnológica de Colombia, 2019-05-01)
Los virus de la leucemia felina (ViLeF) e inmunodeficiencia felina (VIF) están clasificados dentro de la familia Retroviridae y son patógenos que afectan a los gatos domésticos. Estos retrovirus felinos tienen alta capacidad ...