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Fetal metabolic programming and epigenetic modifications: a systems biology approach
(Nature Publishing Group, 2013-04)
A growing body of evidence supports the notion that epigenetic changes such as DNA methylation and histone modifications, both involving chromatin remodeling, contribute to fetal metabolic programming. We use a combination ...
A low maternal protein diet during pregnancy and lactation induce liver offspring damage, in the rat
(Austin Publishing Group, 2015-01)
Pregnancy and fetal development are periods of rapid growth and cell differentiation when mother and offspring are vulnerable to changes. Adverse events during development can be linked to an increased risk for developing ...
Maternal diets enriched in olive oil regulate lipid metabolism and levels of PPARs and their coactivators in the fetal liver in a rat model of gestational diabetes mellitus
(Elsevier Science Inc., 2020-04)
In a rat model of gestational diabetes mellitus (GDM) programmed in the offspring of neonatal streptozotocin-induced (nSTZ) diabetic rats, lipids are accumulated in the fetal liver in a sex-dependent way. Here, we evaluated ...
Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
(Elsevier, 2013-02)
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, ...
Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas
(BioScientifica, 2013-04)
Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. The primary aim of the study was to examine the effect of a saturated ...
Maternal saturated fat-rich diet promotes leptin resistance in fetal liver lipid catabolism and programs lipid homeostasis impairments in the liver of rat offspring
(Elsevier Inc, 2016-01)
We aimed to analyze if an overload of saturated fat in maternal diet induced lipid metabolic impairments in livers from rat fetuses that persist in the offspring and to identify potential mechanisms involving fetal leptin ...
Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver
(Nature Publishing Group, 2019)
Background/objectives: Maternal obesity together with androgen excess in mice negatively affects placental function and maternal and fetal liver function as demonstrated by increased triglyceride content with dysfunctional ...
Protein malnutrition during fetal programming induces fatty liver in adult male offspring rats
(Servicio Publicaciones Universidad Navarra, 2017-05)
We evaluated the effects of protein malnutrition on liver morphology and physiology in rats subjected to different malnutrition schemes. Pregnant rats were fed with a control diet or a low protein diet (LPD). Male offspring ...
Identification of hepatic progenitor cells in the canine fetal liver
(Elsevier B.V., 2020-12-01)
The liver plays essential roles in human and animal organisms, such as the storage, release, metabolism, and elimination of various endogenous or exogenous substances. Although its vital importance, few treatments are yet ...